Contrasting circulating microbiome in cardiovascular disease patients and healthy individuals

Rajendhran, Jeyaprakash; Shankar, Manoharan; Dinakaran, Vasudevan; Rathinavel, Andiappan; Gunasekaran, Paramasamy

doi:10.1016/j.ijcard.2013.07.232

Cited by 59 publications

(65 citation statements)

References 10 publications

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“…Subsequently, Rajendhran et al [7] described a dysbiosis in the circulating microbiome in CVD patients as compared to clinically healthy subjects by amplicon sequencing of the 16S rRNA gene and observed similar results as the aforementioned study. Successively, the same group analyzed the circulating microbiome and virome by shotgun sequencing of plasma in CVD p atients.…”

Section: Clinical Implications Of Circulating Microbiome In Cvdssupporting

confidence: 71%

“…In continuation with this, presence of blood microbiota and its long-term prognosis in CVD patients was studied for the first time which concluded that perturbations in blood microbiota equilibrium is associated with or linked with the onset of the disease [6]. Successively, another paper on the presence of circulating microbiome in CVD patients presented similar findings [7]. Comprehensively, these publications concluded that Proteobacteria were the dominant circulating bacterial population in CVDs.…”

Section: Introductionmentioning

confidence: 88%

“…Analysis of the circulating microbiome has revealed that bacteria were more enriched in VHD patients than congenital and ischemic heart disease (CHD and IHD) patients with a preponderance of Proteobacteria population [7]. Rheumatic heart disease (RHD), resulting from rheumatic fever caused mostly by Group A Streptococcal infection, is the only cardiac disease with a well-established infectious origin.…”

Section: Valvular Heart Disease (Vhd)mentioning

confidence: 99%

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Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

2017

JCCR

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The circulating microbiome or the blood microbiome has been analysed recently in chronic inflammatory diseases like obesity, diabetes, cirrhosis and cardiovascular diseases (CVDs) in humans. Evidences that microbial components in blood could play a crucial role in the pathophysiological events leading to or during the course of disease continue to mount. The blood microbiome has been investigated primarily by profiling the circulating bacterial and viral elements using high-throughput sequencing technologies. However, the clinical implications of circulating microbiome in humans remain largely unexplored. The evidence for the presence of a stable blood microbiome in CVDs is still questionable. Nevertheless, there is evidence for a link between the circulating microbiome in obesity, diabetes and CVDs, indicating the influence of physiological, biochemical and environmental factors on the circulating microbiome in metabolic diseases. With this background, we explore the reports on the clinical consequences of bacteremia in CVD patients which formed the basis for the analyses on the topic "circulating microbiome".

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Section: Clinical Implications Of Circulating Microbiome In Cvdssupporting

confidence: 71%

Section: Introductionmentioning

confidence: 88%

Section: Valvular Heart Disease (Vhd)mentioning

confidence: 99%

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Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

2017

JCCR

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“…The systematic study of the human microbiome has revealed bacterial associations with inflammatory diseases and conditions previously thought to be sterile events or in which the composition of the microflora was regarded as commensal (45–50). To that end, the relationship of inflammation to the microbiome clearly is of major impact in inflammatory disease and the relationship is bi-directional.…”

Section: Pro-resolving Mediators and The Microbiomementioning

confidence: 99%

Pro-resolving mediators in the regulation of periodontal disease

Dyke¹

2017

Molecular Aspects of Medicine

126

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Periodontitis is an inflammatory disease of the supporting structures of the dentition that is initiated by bacterial that form a biofilm on the surface of the teeth. The pathogenesis of the disease is a result of complex interactions between the biofilm and the host response that results in dysbiosis of the microbiome and dysregulation of the inflammatory response. Current data suggest that the excess inflammation associated with periodontitis is due to a failure of resolution of inflammation pathways. In this review, the relationship between inflammation and microbial dysbiosis is examined in the context of pro-inflammation and pro-resolution mediators and their ability to modify the course of disease. The impact of local oral inflammation on systemic inflammation and the relationship of periodontitis to other inflammatory diseases, including type 2 diabetes and cardiovascular disease is reviewed. Active resolvers of inflammation, including the lipoxins and resolvins, show great promise as therapeutics for the treatment of periodontitis and other inflammatory diseases.

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“…24 Such compounds play a substantial role in the development of a "leaky" gut, which allows toxins to enter the bloodstream and results in inflammation and promotion of CVD, obesity, Type 2 diabetes, and chronic diseases. [25][26][27][28][29][30] The gut microbial complex appears to be a major factor responsible for metabolic and inflammatory diseases, linking inflammation and obesity to additional factors such as alterations in lipid metabolism and insulin signaling. The accumulation of fat promotes a chronic inflammatory state that results in the activation and recruitment of immune cells, which leads to an ongoing, self-perpetuating process.…”

Section: Obesitymentioning

confidence: 99%

Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival

Bodai¹,

Nakata²,

Wong

et al. 2018

TPJ

161

106

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By ignoring the root causes of disease and neglecting to prioritize lifestyle measures for prevention, the medical community is placing people at harm. Advanced nations, influenced by a Western lifestyle, are in the midst of a health crisis, resulting largely from poor lifestyle choices. Epidemiologic, ecologic, and interventional studies have repeatedly indicated that most chronic illnesses, including cardiovascular disease, cancer, and type 2 diabetes, are the result of lifestyles fueled by poor nutrition and physical inactivity.In this article, we describe the practice of lifestyle medicine and its powerful effect on these modern instigators of premature disability and death. We address the economic benefits of prevention-based lifestyle medicine and its effect on our health care system: A system on the verge of bankruptcy. We recommend vital changes to a disastrous course. Many deaths and many causes of pain, suffering, and disability could be circumvented if the medical community could effectively implement and share the power of healthy lifestyle choices. We believe that lifestyle medicine should become the primary approach to the management of chronic conditions and, more importantly, their prevention. For future generations, for our own health, and for the Hippocratic Oath we swore to uphold ("First do no harm"), the medical community must take action. It is our hope that the information presented will inspire our colleagues to pursue lifestyle medicine research and incorporate such practices into their daily care of patients. The time to make this change is now.

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Contrasting circulating microbiome in cardiovascular disease patients and healthy individuals

Cited by 59 publications

References 10 publications

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

Clinical Implications of Circulating Microbiome in Cardiovascular Disease Patients

Pro-resolving mediators in the regulation of periodontal disease

Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival

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