Contrasting effects of vasopressin, desglycinamide-vasopressin and amphetamine on a delayed matching to position task in rats

Sahgal, Arjun

doi:10.1007/bf00179942

Cited by 53 publications

(19 citation statements)

References 29 publications

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“…Matching or non-matching to sample procedures provide a particularly useful way of studying memory processes in humans, other primates and birds, and have recently been applied to rodents (Dunnett 1985;Sahgal 1987). Scopolamine produced a deficit in performance at all delays including zero, but greater at the longer delays.…”

Section: Discussionmentioning

confidence: 99%

“…Experimentally one set of six delays was used: 0, 1, 2, 4, 8, 16 s. Each delay was presented an equal number of times per session and the delay began when the rat nose-poked after the sample lever was retracted. When the animals had reached a constant asymptotic performance on delayed nonmatching to sample, drug studies commenced (see Sahgal 1987).…”

Section: Methodsmentioning

confidence: 99%

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Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats

Murray¹,

Cross²,

Green³

1991

Psychopharmacology

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The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats

Murray¹,

Cross²,

Green³

1991

Psychopharmacology

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“…The training paradigm employed was based on a modification of those previously described (Dunnett, 1985(Dunnett, , 1993Kirkby et al, 1995;Sahgal, 1987). Postnatal day 80 Wistar rats were housed in pairs and autoshaped for lever pressing over a period of 40 days.…”

Section: Delayed Match-to-position Paradigmmentioning

confidence: 99%

H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms

Foley

Prendergast

Barry

et al. 2009

Neuropsychopharmacol

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To further understand the procognitive actions of GSK189254, a histamine H 3 receptor antagonist, we determined its influence on the modulation of hippocampal neural cell adhesion molecule (NCAM) polysialylation (PSA) state, a necessary neuroplastic mechanism for learning and memory consolidation. A 4-day treatment with GSK189254 significantly increased basal expression of dentate polysialylated cells in rats with the maximal effect being observed at 0.03-0.3 mg/kg. At the optimal dose (0.3 mg/kg), GSK189254 enhanced water maze learning and the associated transient increase in NCAM-polysialylated cells. The increase in dentate polysialylated cell frequency induced by GSK189254 was not attributable to enhanced neurogenesis, although it did induce a small, but significant, increase in the survival of these newborn cells. GSK189254 (0.3 mg/kg) was without effect on polysialylated cell frequency in the entorhinal and perirhinal cortex, but significantly increased the diffuse PSA staining observed in the anterior, ventromedial, and dorsomedial aspects of the hypothalamus. Consistent with its ability to enhance the learning-associated, post-training increases in NCAM PSA state, GSK189254 (0.3 mg/kg) reversed the amnesia induced by scopolamine given in the 6-h post-training period after training in an odor discrimination paradigm. Moreover, GSK189254 significantly improved the performance accuracy of a delayed match-to-position paradigm, a task dependent on the prefrontal cortex and degree of cortical arousal, the latter may be related to enhanced NCAM PSA-associated plasticity in the hypothalamus. The procognitive actions of H3 antagonism combined with increased NCAM PSA expression may exert a disease-modifying action in conditions harboring fundamental deficits in NCAM-mediated neuroplasticity, such as schizophrenia and Alzheimer's disease.

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“…The second computer task tested both attention and short-term memory in the form of a delayed response, matching to location-order task. In its simplest form, this was a modified version of the delayed response test used in experimental animals by Dunnett (1985) and Sahgal (1987a). In this task, subjects (1) first demonstrated that they had attended to a "model" sequence of "yellow happy faces" presented consecutively in one of four adjacent boxes on a touch sensitive visual display unit (VDU), by touching the boxes as they appeared.…”

Section: Testsmentioning

confidence: 99%

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

et al. 1992

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This single-blind, placebo controlled study reports on the effects of administering three acute doses of nicotine (0.4, 0.6 and 0.8 mg) subcutaneously to a group of Alzheimer's disease (DAT) patients (n = 22), young adult controls (n = 24), and normal aged controls (n = 24). The study extends our previous findings obtained using smaller groups of subjects. Drug effects were examined on three computerised tests: the first measuring rapid visual information processing, sustained visual attention and reaction time (RVIP task); a delayed response matching to location-order task measuring sustained visual attention and visual short-term memory (DRMLO task); and a finger tapping test measuring simple reaction time (FT task). The critical flicker fusion test (CFF) was used as a measure of perception and the WAIS digit span forwards (DS), of auditory short-term memory. Tests were graded in difficulty, titrated to avoid floor and ceiling effects so that meaningful, direct comparisons between groups could be made. Nicotine significantly improved sustained visual attention (in both RVIP and DRMLO tasks), reaction time (in both FT and RVIP tasks), and perception (CFF task--both ascending and descending thresholds). Nicotine administration did not improve auditory and visual short-term memory. There were no consistent, overall patterns of difference in performance between smokers and non-smokers in the control groups, or between males and females in any group. Despite the absence of change in memory functioning, these results demonstrate that DAT patients have significant perceptual and visual attentional deficits which are improved by nicotine administration.(ABSTRACT TRUNCATED AT 250 WORDS)

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Contrasting effects of vasopressin, desglycinamide-vasopressin and amphetamine on a delayed matching to position task in rats

Cited by 53 publications

References 29 publications

Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats

Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats

H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

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