Important elements of natural climate variations during the last ice age are abrupt temperature increases over Greenland and related warming and cooling periods over Antarctica. Records from Antarctic ice cores have shown that the global carbon cycle also plays a role in these changes. The available data shows that atmospheric CO 2 follows closely temperatures reconstructed from Antarctic ice cores during these variations. Here, we present new high-resolution CO 2 data from Antarctic ice cores, which cover the period between 115,000 and 38,000 y before present. Our measurements show that also smaller Antarctic warming events have an imprint in CO 2 concentrations. Moreover, they indicate that during Marine Isotope Stage (MIS) 5, the peak of millennial CO 2 variations lags the onset of Dansgaard/Oeschger warmings by 250 AE 190 y. During MIS 3, this lag increases significantly to 870 AE 90 y. Considerations of the ocean circulation suggest that the millennial variability associated with the Atlantic Meridional Overturning Circulation (AMOC) undergoes a mode change from MIS 5 to MIS 4 and 3. Ocean carbon inventory estimates imply that during MIS 3 additional carbon is derived from an extended mass of carbon-enriched Antarctic Bottom Water. The absence of such a carbon-enriched water mass in the North Atlantic during MIS 5 can explain the smaller amount of carbon released to the atmosphere after the Antarctic temperature maximum and, hence, the shorter lag. Our new data provides further constraints for transient coupled carbon cycleclimate simulations during the entire last glacial cycle.abrupt climate change | CO2-temperature phasing | ice age variability | paleoclimate | greenhouse gas T he climate of the last glacial period is characterized by low global mean temperatures and a number of interhemispheric variations on time scales of several millennia. In the northern hemisphere, in particular on the Greenland ice sheet, large and very rapid temperature jumps of up to 15°C within a few decades, followed by more steady decreases of temperature, have been identified from ice core analyses (1, 2). 25 of these so-called Dansgaard-Oeschger (DO) events have been found during the last glacial period. For each of these events, an associated Antarctic temperature variation has been also documented in Antarctic ice cores (Antarctic Isotope Maximum [AIM] events) (3). Antarctic temperatures increase siteadily when Greenland is in the cold phase and slowly decrease following the abrupt temperature increase in Greenland during a DO event. This behavior is explained by the concept of an oceanic thermal bipolar seesaw, where variations in the Atlantic Meridional Overturning Circulation (AMOC) and associated changes in heat transport across the equator to the North Atlantic modulate the southern and northern hemisphere temperatures during each of these events (4).Previous reconstructions of atmospheric CO 2 concentrations during these millennial-scale variations show that CO 2 varies largely in parallel with the major AIM events (...