Sanukitoid rocks make up a complete magmatic series with distinct geochemical characteristics of TTG suites and granitoids from modern magmatic arcs and are regarded as markers of the transition from typically Archean geodynamics to modern plate tectonics. Although most known sanukitoid suites formed during the Neoarchean and Mesoarchean, numerous papers have characterized Paleoproterozoic magmatic arc granitoid rocks showing affinity with the sanukitoid series. This work presents new data from field, lithogeochemistry, zircon U-Pb geochronology, and Sm-Nd and Sr isotopic studies on granodioritic granulites with sanukitoid signatures from the Juiz de Fora Complex ( JFC), one of the Paleoproterozoic tectonic components of the Minas-Bahia Orogenic System (MBOS), southern São Francisco Paleocontinent (southeastern Brazil). These rocks crystallized at ~2175 Ma and present values of εNd t between −4.0 and +0.5, T DM between 2.57 and 2.12 Ga, and 87 Sr/ 86 Sr i between 0.6937 and 0.7137. We interpret these rocks as the result of crystallization of magmas from a hybrid mantle source extensively contaminated by crustal material during protracted subduction. In southeastern São Francisco Paleocontinent, the association of sanukitoid rocks with other magmatic arc rocks points to a complex and prolonged Rhyacian accretionary system similar to modern plate tectonics.