2023
DOI: 10.3390/microorganisms11030644
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Contrasting Patterns of Asaia Association with Pyrethroid Resistance Escalation between the Malaria Vectors Anopheles funestus and Anopheles gambiae

Abstract: Microbiome composition has been associated with insecticide resistance in malaria vectors. However, the contribution of major symbionts to the increasingly reported resistance escalation remains unclear. This study explores the possible association of a specific endosymbiont, Asaia spp., with elevated levels of pyrethroid resistance driven by cytochrome P450s enzymes and voltage-gated sodium channel mutations in Anopheles funestus and Anopheles gambiae. Molecular assays were used to detect the symbiont and res… Show more

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Cited by 4 publications
(6 citation statements)
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“…Thus, in RSP the difference between infected and sensitive mosquitoes was greater than in Kisumu, and three bacteria increased resistance in RSP, but only one did so in Kisumu. While this phenomenon has been observed before with other microbes of mosquitoes 18,33 , such as Asaia , this is the first study showing that Pseudomonas increases the insecticide resistance of A. gambiae . One possible mechanism is that the bacteria can degrade permethrin themselves.…”
Section: Discussionsupporting
confidence: 72%
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“…Thus, in RSP the difference between infected and sensitive mosquitoes was greater than in Kisumu, and three bacteria increased resistance in RSP, but only one did so in Kisumu. While this phenomenon has been observed before with other microbes of mosquitoes 18,33 , such as Asaia , this is the first study showing that Pseudomonas increases the insecticide resistance of A. gambiae . One possible mechanism is that the bacteria can degrade permethrin themselves.…”
Section: Discussionsupporting
confidence: 72%
“…An exception is the bacterium Asaia, commonly found in mosquito microbiota, whose insecticidedegrading mechanisms have been studied in controlled experimental settings (Djondji Kamga et al 2023). The paucity of experimental data biases our predictions and makes it difficult to quantify the role of the microbiota in insecticide resistance.…”
Section: Introductionmentioning
confidence: 94%
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