Contrasting patterns of X‐chromosome divergence underlie multiple sex‐ratio polymorphisms in stalk‐eyed flies

Paczolt, Kimberly A.; Reinhardt, Josephine A.; Wilkinson, Gerald S.

doi:10.1111/jeb.13140

Cited by 21 publications

(64 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of different factors set out above make it difficult to predict whether they are sufficient to explain SR's observed frequency of approximately 20% [14,55]. Many could act as stabilizing forces which restrict the spread of drive in a frequency-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

et al. 2019

View full text Add to dashboard Cite

A number of species are affected by Sex-Ratio (SR) meiotic drive, a selfish genetic element located on the X-chromosome that causes dysfunction of Y-bearing sperm. SR is transmitted to up to 100% of offspring, causing extreme sex ratio bias. SR in several species is found in a stable polymorphism at a moderate frequency, suggesting there must be strong frequency-dependent selection resisting its spread. We investigate the effect of SR on female and male egg-to-adult viability in the Malaysian stalk-eyed fly, Teleopsis dalmanni . SR meiotic drive in this species is old, and appears to be broadly stable at a moderate (approx. 20%) frequency. We use large-scale controlled crosses to estimate the strength of selection acting against SR in female and male carriers. We find that SR reduces the egg-to-adult viability of both sexes. In females, homozygous females experience greater reduction in viability ( s f = 0.242) and the deleterious effects of SR are additive ( h = 0.511). The male deficit in viability ( s m = 0.214) is not different from that in homozygous females. The evidence does not support the expectation that deleterious side effects of SR are recessive or sex-limited. We discuss how these reductions in egg-to-adult survival, as well as other forms of selection acting on SR, may maintain the SR polymorphism in this species.

show abstract

Section: Discussionmentioning

confidence: 99%

Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Two markers were used to distinguish SR and ST males. Microsatellite ms395 has a bimodal distribution where large (>218bp) alleles are strongly associated with SR (Johns et al 2005; Cotton et al 2014; Meade et al 2018; Paczolt et al 2017). Comp162710 is an indel marker with a small allele (201bp) found in SR males, and a large allele (286bp) found in ST males (Meade et al 2018).…”

Section: Methodsmentioning

confidence: 99%

“…The loss of Y-bearing sperm leads to the production of strongly female-biased broods (Wilkinson and Sanchez 2001). The SR chromosome (X SR ) exists at moderate frequencies (∼20%) in populations of T. dalmanni (Wilkinson et al 2003; Cotton et al 2014; Paczolt et al 2017) and is estimated to have diverged from a non-driving, standard chromosome (X ST ) approximately 500,000 years ago (Paczolt et al 2017). The gene(s) controlling meiotic drive are located in a large paracentric inversion covering most of the X SR chromosome (Johns et al 2005; Paczolt et al 2017), as is typical of several meiotic drive systems (Lyon 2003; Dyer et al 2007; Pinzone and Dyer 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The SR chromosome (X SR ) exists at moderate frequencies (∼20%) in populations of T. dalmanni (Wilkinson et al 2003; Cotton et al 2014; Paczolt et al 2017) and is estimated to have diverged from a non-driving, standard chromosome (X ST ) approximately 500,000 years ago (Paczolt et al 2017). The gene(s) controlling meiotic drive are located in a large paracentric inversion covering most of the X SR chromosome (Johns et al 2005; Paczolt et al 2017), as is typical of several meiotic drive systems (Lyon 2003; Dyer et al 2007; Pinzone and Dyer 2013). As low frequency inversions are associated with reduced recombination rates, they are subject to weaker natural selection and the accumulation of deleterious mutations (Hoffmann and Rieseberg 2008; Kirkpatrick 2010).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does meiotic drive alter male mate preference?

Finnegan

Nitsche

Mondani

et al. 2019

Preprint

View full text Add to dashboard Cite

Male mate preferences have been demonstrated across a range of species, including the Malaysian stalk-eyed fly, Teleopsis dalmanni. This species is subject to SR, an X-linked male meiotic driver, that causes the dysfunction of Y-sperm and the production all female broods. SR is associated with a low frequency inversion spanning most of the X chromosome that causes reduced organismal fitness. While there has been work considering female avoidance of meiotic drive males, the mating decisions of drive-bearing males have not been considered previously. As drive males are of lower genetic quality they may be less able to bear the cost of choice or may experience weaker selection for its maintenance if they are avoided by females. We investigated preference of drive males using binary choice trials. We confirmed that males prefer to mate with large females (indicative of greater fecundity) but found no evidence that the strength of male mate preference differs between drive and standard males. This suggests that the cost of choice does not restrict male reference among drive males. In a further experiment, we found that large eyespan males showed strong preference whereas small eyespan males showed no preference. This is likely to weaken mate preference in drive males, as on average they have reduced eyespan compared to standard males. In this respect, drive males are subject to and exert weak sexual selection.Lay summaryWe studied male mate preference in stalk-eyed flies. This species suffers from meiotic drive, a selfish genetic element that causes a reduction in sperm production and organismal fitness. We predicted that males with meiotic drive would show weak mate preference. Males preferred to mate with large females, but there was no difference in the strength of preference between drive and non-drive males. Males with larger eyespan showed stronger mate preference. Meiotic drive males usually have reduced eyespan so on average they exert weaker sexual selection on females, but this is mediated by eyespan, not genotype per se.

show abstract

“…Future work will need to determine whether 449 varying levels of food stress enhance or restrict the deleterious effect of the X SR work on the stalk-eyed fly drive system suggested that there were suppressors (Wilkinson et 459 al. 1998), this has not been sustained by further work, either on the autosomes or Y 460 chromosomes (Paczolt et al 2017). Second, polyandry may evolve to limit the spread of SR 461 .…”

Section: Egg-to-adult Viability Of Each Genotype 366mentioning

confidence: 98%

Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

Finnegan

White

Koh

et al. 2019

Preprint

View full text Add to dashboard Cite

23SR meiotic drive is a selfish genetic element located on the X chromosome in a number of 24 species that causes dysfunction of Y-bearing sperm. SR is transmitted to up to 100% of 25 offspring, causing extreme sex ratio bias. SR in several species is found in a stable 26 polymorphism at a moderate frequency, suggesting there must be strong frequency-27 dependent selection resisting its spread. We investigate the effect of SR on female and male 28 egg-to-adult viability in the Malaysian stalk-eyed fly, Teleopsis dalmanni. SR meiotic drive in 29 this species is old, and appears to be broadly stable at a moderate (~20%) frequency. We 30 use large-scale controlled crosses to estimate the strength of selection acting against SR in 31 female and male carriers. We find that SR reduces the egg-to-adult viability of both sexes. In 32 females, homozygous females experience greater reduction in viability (sf = 0.242) and the 33 deleterious effects of SR are additive (ℎ = 0.511). The male deficit in viability (sm = 0.214) is 34 not different from that in homozygous females. The evidence does not support the 35 expectation that deleterious side-effects of SR are recessive or sex-limited. We discuss how 36 these reductions in egg-to-adult survival, as well as other forms of selection acting on SR, 37 act to maintain SR polymorphism in this species. 38 157

show abstract

Contrasting patterns of X‐chromosome divergence underlie multiple sex‐ratio polymorphisms in stalk‐eyed flies

Cited by 21 publications

References 82 publications

Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

Does meiotic drive alter male mate preference?

Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

Contact Info

Product

Resources

About