“…has been docu mented in patients with PBC, although pre cise agreement is lacking [55,56]. However, it must be emphasised that quantitation of numbers of cells does not necessarily reflect function of these cells [57], Functional assays of lymphocyte function have, of necessity, concentrated on peripheral circulating cells which may not be representative of cellular function in the liver. While several centres are starting to clone lymphocytes derived from liver of PBC patients, no studies are as yet published.…”