Contrasting results of DNA content analysis in oral lichen planus

Shi, Linjun; Li, Chenxi; Liu, Wei

doi:10.1111/odi.13132

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…(b) Patient with the history of malignancy. (c) Specifically, patients with the clinical and pathological diagnosis of oral lichen planus (OLP) were excluded in this study due to its extremely low rate of DNA aneuploidy 16 and the diagnosis of OLP being the absence of epithelial dysplasia. 13,14 Consistently, subjects diagnosed as OLP were also excluded in the previous relevant study on OPMD.…”

Section: Patients and Cytobrush Proceduresmentioning

confidence: 99%

DNA aneuploidy with image cytometry for detecting dysplasia and carcinoma in oral potentially malignant disorders: A prospective diagnostic study

Deng

et al. 2020

Cancer Medicine

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Background Current evidence on diagnostic value of aneuploidy with DNA image cytometry (ICM) using brushings for oral potentially malignant disorders (OPMD) is limited by sample size and inconsistent classification criteria of aneuploidy. This study aimed to explore the optimal cut‐off values of DNA content and evaluate the diagnostic accuracy of DNA‐ICM for detecting dysplasia and/or carcinoma in OPMD. Materials and Methods A total of 401 consecutive patients with OPMD were enrolled in this prospective diagnostic study. Brushing and biopsy sample form each patient was processed by DNA‐ICM and histological examination respectively. Results When the optimal cut‐off of at least one aneuploid cell with DNA index (DI) ≥2.3, the area under the curves (AUC) was 0.735 and positive predictive value was 92.7% for detecting dysplasia within OPMD. When the optimal cut‐off of at least one aneuploid cell with DI ≥ 3.5, the AUC was 0.851 and negative predictive values was 96.8% for detecting carcinoma within OPMD. Importantly, multivariate analysis revealed that aneuploidy with DI ≥ 2.3 in OPMD was significantly associated with dysplasia risk (adjusted OR, 5.52; 95%CI, 2.90‐10.51; P < .001), and aneuploidy with DI ≥ 3.5 in OPMD was strongly associated with malignant risk (adjusted OR, 21.05; 95%CI, 9.34‐47.41; P < .001). Conclusions This largest‐scale diagnostic study optimized the criteria of aneuploidy cytology for noninvasive detection of oral dysplasia and carcinoma within OPMD. DNA aneuploidy in OPMD was an independent marker that strongly associated with oral dysplasia/carcinoma. Our findings suggest that DNA‐ICM may serve as a useful noninvasive adjunctive tool for oral cancer and OPMD screening.

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Section: Patients and Cytobrush Proceduresmentioning

confidence: 99%

DNA aneuploidy with image cytometry for detecting dysplasia and carcinoma in oral potentially malignant disorders: A prospective diagnostic study

Deng

et al. 2020

Cancer Medicine

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Chronic ulceration of oral mucosa (2.)

Timková,

Kluknavská,

Ďurovič

et al. 2020

Stomatológ

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ÚvodVredovité lézie s chronickým priebehom s lokalizáciou na slizniciach ústnej dutiny majú často spoľahlivú výpovednú hodnotu a vo svojej manifestácii predstavujú systémové ochorenia. Preto sú obyčajne doménou dermatológov a infektológov. Do tejto skupiny chorôb patria pohlavné špecifické infekčné ochorenia, špecifické infekčné plesňové ochorenia a kožné autoimunitné, vezikulo-bulózne ochorenia. Ak pri intraorálnom vyšetrení máme podozrenie na niektorú z týchto chorôb, odporúčame pacienta poslať k príslušným špecialistom. Po začatí liečby sa môžeme zúčastniť na kontrolných vyšetreniach alebo na aplikáciách lokálnych liečebných Chronické ulcerácie ústnych slizníc (2. časť) Chronic ulceration of oral mucosa (2.

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Contrasting results of DNA content analysis in oral lichen planus

Cited by 2 publications

References 8 publications

DNA aneuploidy with image cytometry for detecting dysplasia and carcinoma in oral potentially malignant disorders: A prospective diagnostic study

DNA aneuploidy with image cytometry for detecting dysplasia and carcinoma in oral potentially malignant disorders: A prospective diagnostic study

Chronic ulceration of oral mucosa (2.)

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