Contrasts Between Patients With Lewy Body Dementia Syndromes and APOE-ε3/ε3 Patients With Late-onset Alzheimer Disease Dementia

Oliveira, Fabricio Ferreira de; Machado, FR; Sampaio, Gustavo; Marin, Sheilla de Medeiros Correia; Chen, Elizabeth; Smith, Marı́lia de Arruda Cardoso; Bertolucci, Paulo Henrique Ferreira

doi:10.1097/nrl.0000000000000045

Cited by 26 publications

(19 citation statements)

References 33 publications

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“…6,28 The incidence of delusions and hallucinations tends to be dissociated, considering that in AD delusions are usually more common than hallucinations, while in Lewy body dementia syndromes, hallucinations are more common than delusions. 31 Though APOE-e4 carrier status seems to predispose to late-onset depression, 3 particularly in women, 32 we did not find correlations with dysphoria in our sample. Nevertheless, one study showed that women have earlier AD onset when they are APOE-e4 carriers with a history of depression, 33 confirming that gender differences might affect dementia onset.…”

Section: 019mentioning

confidence: 49%

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Oliveira

Chen

Smith

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Results: Considering 201 patients, only APOE-e4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs11669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Conclusion: Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.

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Section: 019mentioning

confidence: 49%

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Oliveira

Chen

Smith

et al. 2017

Rev. Bras. Psiquiatr.

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“…Future revisions could consider research findings and features described by investigators in other parts of the world. 49,50 The LBD- Findings from this study will be helpful in providing the initial evidence base for the use of the LBD-MOD in clinical research. The LBD-MOD appears to provide sufficient clinical discrimination between DLB and AD so that it can aid in diverse clinical research programs such as case-ascertainment in epidemiological studies, biomarker studies, cross-sectional and longitudinal studies, and clinicopathological correlation.…”

Section: Discussionmentioning

confidence: 97%

“…The LBD‐MOD was created by dementia and movement disorder experts from the United States. Future revisions could consider research findings and features described by investigators in other parts of the world 49,50 . The LBD‐MOD was validated in the context of an academic research setting where the prevalence of MCI and dementia in general, and DLB in particular, are high, and the participants tend to be highly educated and predominantly White.…”

Section: Discussionmentioning

confidence: 99%

Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD)

Galvin

Chrisphonte

Cohen

et al. 2021

Alzheimer's & Dementia

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“…Patients with DLB present with not only cognitive impairment as do patients with ADD, but also various symptoms such as Parkinsonism, visual hallucinations, REM sleep behavioral disorder (RBD), cognitive fluctuation, and depressive mood from early stages onwards (1). Therefore, various factors contribute to deficits in activities of daily living (ADL) (2), and family caregivers experience a high burden (3)(4)(5) in cases of patients with DLB rather than those with ADD, although there is a report that shows no difference in caregiver burden between DLB and ADD (6).…”

Section: Introductionmentioning

confidence: 99%

Impact of Behavioral and Psychological Symptoms on Caregiver Burden in Patients With Dementia With Lewy Bodies

et al. 2021

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Background/Objective: Behavioral and psychological symptoms of dementia (BPSD) have been reported to affect caregiver burden in patients with dementia with Lewy bodies (DLB). However, the factor structure of BPSD and the factors that affect caregiver burden in DLB remain unknown. This study sought to classify BPSD and to reveal what type of BPSD affects caregiver burden in patients with DLB.Methods: We collected data on neuropsychiatric inventory-plus (NPI-plus), Zarit Burden Interview (ZBI), Mini-Mental State Examination (MMSE), Lawton's Instrumental Activities of Daily Living and Physical Self-Maintenance Scale (IADL/PSMS), age, and sex of 102 patients with probable DLB. An exploratory factor analysis of 13 items of the NPI-plus was carried out to classify BPSD. Multivariate regression analyses were conducted to extract the clinical variables related to caregiver burden, including factors resulting from the aforementioned factor analysis.Results: The mean age and MMSE score were 78.6 (5.6) and 20.2 (5.2), respectively. Factor analysis revealed four factors of “psychosis,” “affection,” “wakefulness,” and “hyperactivity.” “Psychosis” and “affection” factors as well as MMSE, IADL, and PSMS were significantly associated with ZBI. Multivariate regression analyses revealed that the total score of ZBI was associated with “psychosis,” “affection,” and IADL, that the personal strain score of ZBI was associated with “affection” and IADL, and that the role strain score of ZBI was associated with “wakefulness” and IADL.Conclusions: BPSD in DLB consists of three factors common to Alzheimer's disease and a specific “wakefulness” factor. In addition to IADL, each BPSD factor would affect caregiver burden in different ways in DLB.

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Contrasts Between Patients With Lewy Body Dementia Syndromes and APOE-ε3/ε3 Patients With Late-onset Alzheimer Disease Dementia

Abstract: Functional performance, visuospatial skills, and behavioral symptoms are helpful for differential diagnoses between LBD and AD. Cerebrovascular risk might be more important for AD pathogenesis, whereas environmental factors might impact development of LBD.

Cited by 26 publications

References 33 publications

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD)

Impact of Behavioral and Psychological Symptoms on Caregiver Burden in Patients With Dementia With Lewy Bodies

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