Contribución del foramen oval permeable a la etiopatogenia del síndrome de intestino irritable

Álvarez-Fernández, J.A.; Alarcón–Fernández, Onofre; Pérez-Quintero, Raquel

doi:10.1016/s0014-2565(09)70879-3

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…The posterior microcirculation abnormalities were related to the dysfunction of the autonomic system with the manifestation of photophobia ( 38 , 39 ). In addition, prior clinical surveys proved that paradoxical embolism induced by RLS could damage both cerebral and peripheral microcirculation, leading to an alteration of serotonin, pro-inflammatory bradykinin, or neurotensin metabolism ( 40 ). These metabolic impairments also had an adverse effect on autonomic function, causing disturbances in the response to visual stimuli ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Dong¹,

Ji²,

Li³

et al. 2023

Front. Neurol.

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BackgroundHypersensitivity to light is a common symptom associated with dysfunction of the occipital region. Earlier studies also suggested that clinically significant right-to-left shunt (RLS) could increase occipital cortical excitability associated with the occurrence of migraine. The aim of this study was to investigate the relationship between RLS and photosensitivity.MethodsThis cross-sectional observational study included the residents aged 18–55 years living in the Mianzhu community between November 2021 and October 2022. Photosensitivity was evaluated using the Photosensitivity Assessment Questionnaire along with baseline clinical data through face-to-face interviews. After the interviews, contrast-transthoracic echocardiography (cTTE) was performed to detect RLS. Inverse probability weighting (IPW) was used to reduce selection bias. Photosensitivity score was compared between individuals with and without significant RLS using multivariable linear regression based on IPW.ResultsA total of 829 participants containing 759 healthy controls and 70 migraineurs were finally included in the analysis. Multivariable linear regression analysis showed that migraine (β = 0.422; 95% CI: 0.086–0.759; p = 0.014) and clinically significant RLS (β = 1.115; 95% CI: 0.760–1.470; p < 0.001) were related to higher photosensitivity score. Subgroup analysis revealed that clinically significant RLS had a positive effect on hypersensitivity to light in the healthy population (β = 0.763; 95% CI: 0.332–1.195; p < 0.001) or migraineurs (β = 1.459; 95% CI: 0.271–2.647; p = 0.010). There was also a significant interaction between RLS and migraine for the association with photophobia (pinteraction = 0.009).ConclusionRLS is associated with photosensitivity independently and might exacerbate photophobia in migraineurs. Future studies with RLS closure are needed to validate the findings.Trial registrationThis study was registered at the Chinese Clinical Trial Register, Natural Population Cohort Study of West China Hospital of Sichuan University, ID: ChiCTR1900024623, URL: https://www.chictr.org.cn/showproj.html?proj=40590.

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Section: Discussionmentioning

confidence: 99%

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Dong¹,

Ji²,

Li³

et al. 2023

Front. Neurol.

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Section: Introductionmentioning

confidence: 99%

“…Traditional risk factors for ischemic stroke include body stressors that may lead to autonomic dysfunction, which can be reflected by beat‐to‐beat heart rate variability (HRV) 9 . Previous studies have reported that PFO is closely related to autonomic dysfunctional disorders such as irritable bowel syndrome 10 . Thus, it is worth exploring the characteristics of autonomic function in migraine patients with PFO and the effect of PFO closure on autonomic functioning.…”

Section: Introductionmentioning

confidence: 99%

“… 9 Previous studies have reported that PFO is closely related to autonomic dysfunctional disorders such as irritable bowel syndrome. 10 Thus, it is worth exploring the characteristics of autonomic function in migraine patients with PFO and the effect of PFO closure on autonomic functioning. In the present study, we investigated whether PFO closure affects dCA function, blood biomarkers, and autonomic function in severe migraine patients.…”

Section: Introductionmentioning

confidence: 99%

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Changes in cerebral autoregulation, stroke‐related blood biomarkers, and autonomic regulation after patent foramen ovale closure in severe migraine patients

Guo

Gao

et al. 2023

CNS Neurosci Ther

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AimsThis study aimed to investigate changes in dynamic cerebral autoregulation (dCA), 20 stroke‐related blood biomarkers, and autonomic regulation after patent foramen ovale (PFO) closure in severe migraine patients.MethodsPatent foramen ovale severe migraine patients, matched non‐PFO severe migraine patients, and healthy controls were included. dCA and autonomic regulation were evaluated in each participant at baseline, and within 48‐h and 30 days after closure in PFO migraineurs. A panel of stroke‐related blood biomarkers was detected pre‐surgically in arterial‐and venous blood, and post‐surgically in the arterial blood in PFO migraineurs.ResultsForty‐five PFO severe migraine patients, 50 non‐PFO severe migraine patients, and 50 controls were enrolled. The baseline dCA function of PFO migraineurs was significantly lower than that of non‐PFO migraineurs and controls but was rapidly improved with PFO closure, remaining stable at 1‐month follow‐up. Arterial blood platelet‐derived growth factor‐BB (PDGF‐BB) levels were higher in PFO migraineurs than in controls, which was immediately and significantly reduced after closure. No differences in autonomic regulation were observed among the three groups.ConclusionPatent foramen ovale closure can improve dCA and alter elevated arterial PDGF‐BB levels in migraine patients with PFO, both of which may be related to the preventive effect of PFO closure on stroke occurrence/recurrence.

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Contribución del foramen oval permeable a la etiopatogenia del síndrome de intestino irritable

Cited by 2 publications

References 19 publications

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Changes in cerebral autoregulation, stroke‐related blood biomarkers, and autonomic regulation after patent foramen ovale closure in severe migraine patients

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