Contributing factors to the outcome of primary malignant chest wall tumors

Rahman, Abdel Rahman M. Abdel; Rahouma, Mohamed; Gaafar, Rabab; Bahaa, Sherif; Loay, Iman; Kamel, Mohamed; Abdel-Baki, Hoda M.; Yahia, Maha

doi:10.21037/jtd.2017.11.61

Cited by 15 publications

(14 citation statements)

References 33 publications

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“…Furthermore, regarding primary thoracic wall tumors, Bagheri et al (5) reported that the presence of distal metastasis significantly worsened prognosis, and any significant effect on survival was regardless of whether reconstruction was performed. According to previous studies, the 5-year survival rates are 21–61% in patients with lung cancer who present with thoracic wall invasion (1,9) and 73.9–88.5% in those with tumors arising from the soft tissues of the thoracic wall (10,19), results that are comparable to those of our study. However, in our study, neither the R factor nor the N factor caused statistically significant differences in prognosis.…”

Section: Discussionsupporting

confidence: 91%

“…With regard to the postoperative overall survival rate, the 5-year survival rates were 53.4% in the lung tumor group and 77.0% in the musculoskeletal tumor group. With regard to the postoperative outcomes of individuals with lung cancer who presented with thoracic wall invasion, positive margin (R1,2) and lymph node metastasis (N1,2) have been reported as poor prognostic factors (1,9,10). The number of resected ribs and thoracic wall invasion reportedly did not affect prognosis (1).…”

Section: Discussionmentioning

confidence: 99%

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Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection

et al. 2019

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Postoperative complications of thoracic wall resection include respiratory complications, skin necrosis and infection. The aim of the present study was to examine postoperative complications in patients who required combined thoracic wall resection during the surgical removal of a tumor. The present study included 68 patients; there were 50 patients with lung tumors and 18 patients with musculoskeletal tumors. The clinical factors associated with complications were compared between the two groups. Preoperative and postoperative pulmonary function tests were performed to examine the residual pulmonary function in 16 patients. Thoracic cage reconstruction was performed in 46 patients. Postoperative complications occurred in 30 (44.1%) patients, and one patient died from postoperative pneumonitis. Compared with the pulmonary function preoperative test results, the postoperative results revealed a decrease in the mean vital capacity percentage and an increase in the mean forced expiratory volume within 1 sec as a percent of the forced vital capacity. In patients with lung tumors, pneumonectomy can result in an increased rate of complications following thoracic wall resection. Residual pulmonary function is affected by impaired thoracic cage expansion and removal of the lung. However, the results of the present study demonstrated that these complications can be somewhat stabilized by thoracic wall reconstruction.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection

et al. 2019

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“…Chondrosarcoma is the most common primary malignant chest wall tumors. [4,10] Compared with other sarcomas in the chest wall, chondrosarcoma had a better survival. [11] Although chest wall chondrosarcoma is a rare malignancy, it has the potential for metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Contrary to our hypothesis, patients who received radiotherapy had significantly inferior OS and CSS compared with those who did not. Abdel Rahman et al [10] reviewed 98 patients with malignant chest wall tumors and reported that absence of adjuvant radiotherapy or chemotherapy was a univariate predictor rather than an independent predictor associated with better disease-free survival. Multi-center prospective studies are needed to confirm the role of radiotherapy in chest wall chondrosarcoma in the future.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and prognostic analysis of patients with chest wall chondrosarcoma

Gao

Zhou²,

Wang

et al. 2019

Medicine

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Chest wall chondrosarcoma is a rare malignant tumor of the bone. This study is aimed to identify the prognostic determinants of chest wall chondrosarcoma. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify patients with chest wall chondrosarcoma from 1973 to 2015. Statistical analyses were performed using Kaplan–Meier method and Cox regression proportional hazards. A total of 779 patients were identified from the SEER database. The overall survival (OS) and cancer-specific survival (CSS) rates of the entire group at 10 years were 66.2% and 77.2%, respectively. On multivariate Cox regression, age ≤40 years, localized tumor stage, low tumor grade, surgery, and no radiotherapy were significantly associated with improved both OS and CSS. This study may help clinicians to predict survival of patients with chest wall chondrosarcoma and to provide appropriate treatment recommendations.

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“…3 –9 The largest study of wide resection for curative intent for PCWT consists of 98 patients, 6 and the majority of studies focus on a few specific diagnoses, primarily chondrosarcomas. 4,6,7,10 –15 At our institution, all PCWTs are considered as a heterogenous group of tumors that receive similar preoperative evaluations and surgical resections, regardless of perioperative chemotherapy or radiation therapy protocols. We sought to determine the overall survival (OS) and tumor recurrence in PCWT patients with a broad range of diagnoses receiving surgical resection for curative intent by a single surgeon at our tertiary referral specialty center.…”

Section: Introductionmentioning

confidence: 99%

Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience

Shah

Komperda

Mavanur

et al. 2019

J Orthop Surg (Hong Kong)

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Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence (p < 0.001) but not significantly different between pathology grades (p ¼ 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.

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Contributing factors to the outcome of primary malignant chest wall tumors

Cited by 15 publications

References 33 publications

Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection

Surgical complication and postoperative pulmonary function in patients undergoing tumor surgery with thoracic wall resection

Clinical features and prognostic analysis of patients with chest wall chondrosarcoma

Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience

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