Contribution cytochimique et histoautoradiographique à l'étude du métabolisme et de la synthèse des ADN dans des cellules animales cultivées in vitro—II

Helical Filaments in Astrocytic Mitochondria of the Corpus Striatum in the Rat

“…Steinert (26) showed that, in the kinetoplast, two parts are seen, one being fibrous and Feulgen-positive, and the other of mitochondrial nature. Ch~vremont et al (5), in experimental studies on chicken embryo fibroblasts, described that mitochondria accumulate DNA and transport it to the nucleus. In view of these observations it could not be completely excluded that the helical filaments described in the present paper contain DNA, 2 and specific tests for the elucidation of this point should be carried out.…”

MITOCHONDRIAL INCORPORATION OF TRITIATED THYMIDINE IN TETRAHYMENA PYRIFORMIS

“…Ch~vremont et al (2,3) have found Hn-thymidine incorporation in chick embryo mitochondria after treatment of living cells with DNase or reduced temperatures of 16°C. The authors conclude that under these conditions D N A is synthesized in the cytoplasm and transported to the nucleus by mitochondria.…”

The Reductive Hotspot Hypothesis: An Update

“…His new suggestion was that the most important site of this damage might be the mitochondrion. This was supported by three items of evidence that had emerged since the publication of the free radical theory: mitochondria are a prominent source of toxic reactive oxygen speciesindeed, probably the predominant physiological source (3); mitochondria possess their own DNA (4,5), which, unlike lipids and proteins, cannot be reconstructed from scratch when damaged; and dietary antioxidants can substantially increase the mean lifespan of mice but cannot increase their maximum lifespan (6).…”