Contribution of Adenosine to the Increase in Skeletal Muscle Blood Flow Caused by Manual Acupuncture in Rats

Satoh, Hisashi; Nagaoka, Satomi; Izutani, Yasuyuki; Okubo, Masamichi; Kimura, Keisaku; Mizunuma, Kazuyuki; Sumiya, Eiji

doi:10.1136/acupmed-2016-011152

Cited by 11 publications

(4 citation statements)

References 20 publications

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“… 18 and Shinbara et al. 17 both demonstrated that blood flow within the skeletal muscle can be significantly increased following acupuncture. Acupuncture has further been shown to reduce exercise-induced muscle soreness 19 and attenuate inflammation at various joints throughout the body such as the elbow, 16 the knee, 20 and the shoulder joint.…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Symons¹,

Park²,

Kim³

et al. 2023

Integrative Medicine Research

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Section: Introductionmentioning

confidence: 99%

“… 14 Although acupuncture has been used predominantly to manage pain under pathological conditions, 15 , 16 recent studies suggest that acupuncture can be used for the treatment of musculoskeletal disorders. 17 Nagaoka et al. 18 and Shinbara et al.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Symons¹,

Park²,

Kim³

et al. 2023

Integrative Medicine Research

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“…20–22 Acupuncture can also be used to control body weight and attenuate stroke-induced learning and memory deficits. 23,24 Recently, many studies have demonstrated that the anti-nociceptive properties of acupuncture are mediated by the release of endogenous opiates 25–27 and adenosine28, 29 and may also be related to changes in the expression of various proteins, including the NMDARs, ASIC3, TRPV1, TRPV4 and Nav channels. 30–33 Recent studies have demonstrated that TRPV1 or pERK is increased in the peripheral dorsal root ganglion (DRG), central amygdala and thalamus in the acid saline injection-induced mouse FM model.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture reduces fibromyalgia pain by downregulating the TRPV1–pERK signalling pathway in the mouse brain

et al. 2020

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Background: Acupuncture has been clinically recommended as a method of pain relief by the World Health Organization and is widely used by medical doctors. Fibromyalgia (FM) pain has a complex physiological and psychological origin and can be pharmacologically treated with duloxetine, milnacipran and pregabalin. However, these drugs produce undesirable side effects, such as headaches, nausea and diarrhoea. Acupuncture may serve as an effective alternative treatment for pain relief with few side effects. Aims: We hypothesised that acupuncture would reduce FM pain by influencing transient receptor potential cation channel subfamily V member 1 (TRPV1) and the downstream phosphorylated extracellular signal-regulated kinases (pERK), which are located in the central thalamus, amygdala and cortex. Methods: A FM mouse model was established by injecting two doses of acid saline into 32 female C57/B6 mice. The mice were then assigned to different subgroups (n=8 each) and treated with electroacupuncture (EA) or EA sham control. TRPV1 and pERK expression levels were measured using Western blotting and immunohistochemistry. Results: Our results demonstrated that the expression of TRPV1 and pERK in the thalamus, amygdala and somatosensory cortex was normal in the control mice, but significantly increased in FM mice; these FM-induced changes in expression were attenuated by EA. Conclusion: Our data suggest that EA can reverse the central sensitisation of the TRPV1-ERK signalling pathway in the mouse brain. Thus, our findings provide mechanistic evidence supporting the potential therapeutic efficacy of EA for treating FM pain.

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“…Subsequently, AP research in the field of purinergic signalling started to flourish and a large set of data has been accumulated on changes in purine (ATP, adenosine) concentrations, both locally and in the CNS, induced by manual acupuncture, electroacupuncture, or moxibustion [12][13][14][15][16][17]. The participation of purinergic receptors (P1: A1, A2a, A2b, A3) [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], (P2: P2X2, P2X3, P2X7, P2Y1, P2Y13) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52], and neuronal pathways bearing these receptors [53,54] has been confirmed in different AP-sensitive conditions (pain, inflammation, myocardial ischemia, obesity, cerebral ischemia).…”

mentioning

confidence: 99%

Tribute to Prof. Geoffrey Burnstock: his contribution to acupuncture

Tang

Illéš

2020

Purinergic Signalling

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As the creator of purinergic signalling [1], Prof. Geoffrey Burnstock (1929-2020) [2] also made important contributions to the science of acupuncture (AP). AP family procedures include mechanical needling, electroacupuncture, moxibustion, cupping, etc. [3]. His insightful hypothesis on the natural scientific basis of AP in 2009 [4] led to an explosion of research worldwide that aimed to explaining how purinergic signalling contributes to AP. The development of our understanding on AP-induced analgesia has been elaborately documented in the past [5-7]; hence, in this article, we summarize Geoff's distinguished contribution to, and profound impact on, AP and also disclose some personal accounts of his impact on our personal careers in specific, and on the Chinese AP community on a larger scale.

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Contribution of Adenosine to the Increase in Skeletal Muscle Blood Flow Caused by Manual Acupuncture in Rats

Abstract: The results suggest that adenosine leads to an increase in MBF caused by MA. Adenosine may play a role in acupuncture analgesia by washing out algesic substances. Further studies are needed in order to elucidate the precise mechanism.

Cited by 11 publications

References 20 publications

Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Electroacupuncture reduces fibromyalgia pain by downregulating the TRPV1–pERK signalling pathway in the mouse brain

Tribute to Prof. Geoffrey Burnstock: his contribution to acupuncture

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