Contribution of Agrobacterium to Morgellons Disease.

Stricker, Raphael B.; Savely, V. R.; Zaltsman, Adi; Citovsky, Vitaly

doi:10.1097/00042871-200701010-00294

Cited by 9 publications

(15 citation statements)

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“…20 A cellulose-protein complex was identified as a minor constituent of mammalian connective tissue, with increased amounts of such material noted in tissues from scleroderma patients and patients with other pathological skin conditions 51. The cellulose-producing plant pathogen Agrobacterium has been shown to infect nonplant species including humans, and polymerase chain reaction screening of tissue samples from five patients with Morgellons disease indicates the presence of Agrobacterium genes, implying a possible etiological involvement 29,52. However, further polymerase chain reaction testing has yet to reveal a link between tissue samples and pathogens, showing no significant statistical difference between negative controls and patients with Morgellons disease 30…”

Section: Morgellons Diseasementioning

confidence: 99%

Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

Middelveen¹,

Stricker²

2011

CCID

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Bovine digital dermatitis is an emerging infectious disease that causes lameness, decreased milk production, and weight loss in livestock. Proliferative stages of bovine digital dermatitis demonstrate keratin filament formation in skin above the hooves in affected animals. The multifactorial etiology of digital dermatitis is not well understood, but spirochetes and other coinfecting microorganisms have been implicated in the pathogenesis of this veterinary illness. Morgellons disease is an emerging human dermopathy characterized by the presence of filamentous fibers of undetermined composition, both in lesions and subdermally. While the etiology of Morgellons disease is unknown, there is serological and clinical evidence linking this phenomenon to Lyme borreliosis and coinfecting tick-borne agents. Although the microscopy of Morgellons filaments has been described in the medical literature, the structure and pathogenesis of these fibers is poorly understood. In contrast, most microscopy of digital dermatitis has focused on associated pathogens and histology rather than the morphology of late-stage filamentous fibers. Clinical, laboratory, and microscopic characteristics of these two diseases are compared.

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Section: Morgellons Diseasementioning

confidence: 99%

Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

Middelveen¹,

Stricker²

2011

CCID

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“…In these complexes, the presence of more than one aromatic rings results in a complex multiplet pattern in aromatic region. However, two doublets and a triplet are observed at 6.72-6.77, 6.27-6.35 and 6.45-6.58 ppm, respectively, with normal 3 J ( 1 H, 1 H) coupling constant values in complexes (1)(2)(3)(4) which find the position of three protons of aromatic ring having methylenedioxy group.…”

Section: H Nmr Spectroscopymentioning

confidence: 95%

Dimethyltin(IV) Derivatives of Biologically Potent Substituted Phenylacrylic Acids: Synthesis, Chemical Characterization and Inhibitory Effects on Agrobacterium tumefaciens

et al. 2009

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Effect of dimethyltin(IV) complexes of different substituted phenyl acrylic acids on the ability of Agrobacterium tumefaciens to cause tumours in plants was studied by using potato discs. The results demonstrated significant inhibition of tumours formation. All the compounds were synthesized and characterized by using analytical techniques, i.e. FTIR, multinuclear NMR ((1)H, (13)C, (19)F and (119)Sn) and mass spectrometry. These studies explain that dimethyltin(IV) derivatives exist in a deformed octahedral environment known as skew trapezoidal geometry with four strong and two weaker bonds.

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“…A brief publication in Journal of Investigative Medicine reported the finding of Agrobacterium genes in two Morgellons patients and the authors including Citovsky explained why they looked for Agrobacterium [135]: "Morgellons skin fibers appear to contain cellulose. This observation indicates possible involvement of pathogenic Agrobacterium, which is known to produce cellulose fibers at infection sites within host tissues.…”

Section: Agrobacterium and Morgellons Diseasementioning

confidence: 99%

The New Genetics and Natural versus Artificial Genetic Modification

Ho¹

2013

Entropy

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Abstract:The original rationale and impetus for artificial genetic modification was the "central dogma" of molecular biology that assumed DNA carries all the instructions for making an organism, which are transmitted via RNA to protein to biological function in linear causal chains. This is contrary to the reality of the "fluid genome" that has emerged since the mid-1970s. In order to survive, the organism needs to engage in natural genetic modification in real time, an exquisitely precise molecular dance of life with RNA and DNA responding to and participating in "downstream" biological functions. Artificial genetic modification, in contrast, is crude, imprecise, and interferes with the natural process. It drives natural systems towards maximum biosemiotic entropy as the perturbations are propagated and amplified through the complex cascades of interactions between subsystems that are essential for health and longevity.

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Contribution of Agrobacterium to Morgellons Disease.

Cited by 9 publications

References 0 publications

Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

Dimethyltin(IV) Derivatives of Biologically Potent Substituted Phenylacrylic Acids: Synthesis, Chemical Characterization and Inhibitory Effects on Agrobacterium tumefaciens

The New Genetics and Natural versus Artificial Genetic Modification

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