Contribution of alcohol and drug co-use to substance use problems: Data from a nationally-representative sample of US adults who have never been to treatment

Abstract

Aims: Combined use of alcohol with drugs elevates risk for problems including injury and intoxicated driving. We assessed contributions of heavy drinking (5+ men/4+ women), drug use (cannabis and other drugs) and simultaneous co-use to DSM-5 alcohol use disorder (AUD) and drug abuse (DA). We expected co-use to increase risk for AUD and DA. Methods: Using population-weighted data from adults in the 2014–15 National Alcohol Survey who had never been to treatment (N=3386 drinkers, 50% male, 13% Hispanic, 11% Black, mean age 45; N=439 drug users, 56% male, 20% Hispanic, 15% Black, mean age 36), we tested hypotheses using logistic regression adjusting for demographics, family history of alcohol problems and impulsivity. Results: 10% of drinkers and 26% of drug users met criteria for mild AUD; <1% of drinkers and 4% of drug users met criteria for DA. Heavy drinking significantly increased risk for AUD, as did monthly or weekly use of cannabis. When simultaneous co-use was added, increased risk associated with cannabis use was reduced to non-significance. Weekly cannabis use, weekly use of other drugs and simultaneous drug and alcohol co-use were associated with significantly elevated risk of DA. In bivariate analyses, simultaneous co-use was associated with significantly greater endorsement of each of the separate AUD and DA symptom domains, including alcohol craving, tolerance and withdrawal, as well as drug and alcohol social and physical health problems. Conclusion: Healthcare providers should screen for simultaneous co-use of alcohol and drugs to help identify patients who may benefit from substance abuse treatment.

Risks Associated with Mid level Cannabis Use Among People Treated for Alcohol Use Disorder

“…We were unable to adjust for use of drugs other than cannabis. Recent work with an untreated sample of drinkers from the 2015 NAS ( N = 2,813) has shown other drug use to be an important predictor of both drug and AUDs (Karriker‐Jaffe et al., ). Other drug use also was a stronger predictor of fewer alcohol‐abstinent days in comparison with cannabis use as a predictor of fewer alcohol‐abstinent days in the study of individuals in treatment (Subbaraman et al., ).…”

Common and separable neural alterations in substance use disorders: A coordinate‐based meta‐analyses of functional neuroimaging studies in humans

“…We examined differences and overlaps between all six pairs of substances. The comparisons were done without specific a priori hypotheses (although co-use of the substances is often reported in research, (see [Karriker-Jaffe, Subbaraman, Greenfield, & Kerr, 2018]) in the following manner: cannabis versus cocaine, alcohol versus cocaine, alcohol versus cannabis, cannabis versus nicotine, cocaine versus nicotine, and nicotine versus alcohol. ALE analysis for individual substance groups was conducted first.…”

Common and separable neural alterations in substance use disorders: evidence from coordinate-based meta-analyses of functional neuroimaging studies in human

“…We examined differences and overlaps between all six pairs of substances. The comparisons were done without specific a priori hypotheses (although co-use of the substances is often reported in research, (see [38])) in the following manner: cannabis versus cocaine, alcohol versus cocaine, alcohol versus cannabis, cannabis versus nicotine, cocaine versus nicotine, and nicotine versus alcohol. ALE analysis for individual substance groups was conducted first.…”