Contribution of Anales de Pediatría to the international visibility of Spanish paediatric research in the Web of Science (2010–2014)

Abad-García, Francisca; González‐Teruel, Aurora; Sánchez, Gonzalo Solís

doi:10.1016/j.anpede.2016.10.006

Cited by 1 publication

(1 citation statement)

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“…VThf fluctuates in the short term, but remains very close to the target value over longer periods [19]. The increase in ΔPhf necessary to maintain a constant VThf measured in the airway opening is damped as it traverses the airways to the alveoli, especially at higher frequencies [20][21][22], until it falls to a minimum at the resonant frequency, as described in several studies [21,[23][24][25][26]. This optimal frequency, which results in adequate gas transport during HFOV and the least harmful pressures, depends on underlying lung condition wherein higher frequencies are better suited to pulmonary diseases with low compliance and short time constants such as RDS in preterm infants [19,21].…”

Section: Introductionmentioning

confidence: 99%

Effect of a new respiratory care bundle on bronchopulmonary dysplasia in preterm neonates

et al. 2020

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The development of devices that can fix the tidal volume in high-frequency oscillatory ventilation (HFOV) has allowed for a significant improvement in the management of HFOV. At our institution, this had led to the earlier use of HFOV and promoted a change in the treatment strategy involving the use of higher frequencies (above 15 Hz) and lower high-frequency tidal volumes (VThf). The purpose of this observational study was to assess how survival without bronchopulmonary dysplasia grades 2 and 3 (SF-BPD) is influenced by these modifications in the respiratory strategy applied to preterm infants (gestational age < 32 weeks at birth) who required mechanical ventilation (MV) in the first 3 days of life. We compared a baseline period (2012-2013) against a period in which this strategy had been fully implemented (2016-2017). A total of 182 patients were exposed to MV in the first 3 days of life being a higher proportion on HFOV at day 3 in the second period 79.5% (n 35) in 2016-2017 vs 55.4% (n 31) in 2012-2013. After adjusting for perinatal risk factors, the second period is associated with an increased rate of SF-BPD (OR 2.28; CI 95% 1.072-4.878); this effect is more evident in neonates born at a gestational age of less than 29 weeks (OR 4.87; 95% CI 1.9-12.48). Conclusions : The early use of HFOV combined with the use of higher frequencies and very low VT was associated with an increase in the study population's SF-BPD. What is Known: • High-frequency ventilation with volume guarantee improve ventilation stability and has been shown to reduce lung damage in animal models. What is New: • The strategy of an earlier use of high-frequency oscillatory ventilation combined with the use of higher frequencies and lower tidal volume is associated to an increase in survival without bronchopulmonary dysplasia in our population of preterm infants. Keywords High-frequencyventilation. Lung protection. Bronchopulmonary dysplasia. Ventilatory-induced lung injury. Target tidal volume. Preterm infants Abbreviations ΔPhf Delta pressure BPD Bronchopulmonary dysplasia type 2-3 BW Birth weight CMV Conventional mechanical ventilation CRIB Critical index for babies DOL Days of life GA Gestational age HFOV High-frequency oscillatory ventilation Hz Hertz INSURE Intubation-surfactant administration-extubation LISA Less-invasive surfactant administration MV Mechanical ventilation nCPAP Nasal continuous airway pressure NEC Necrotizing enterocolitis Communicated by Daniele De Luca

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