This study investigates the relationship between Indoor Air Quality (IAQ) and air duct cleanliness, addressing the rising concern for human well-being. Airborne contaminants like dust, mold, and bacteria are identified as significant threats to IAQ, with potential health consequences. The study will also explore the several established safety and health guidelines and duct characteristics that influenced IAQ. Consequently, the primary research goal is to examine the relationship between duct cleanliness and airborne contaminants in the building environment and determine whether air duct cleaning effectively reduces these contaminants. By thoroughly reviewing studies and established standards, we examine IAQ contaminants and explore the effects of duct cleaning, along with its potential health advantages. Findings emphasize duct cleaning's potential to enhance IAQ, reduce exposure to pollutants, and its importance for building owners, facility managers, and stakeholders in safeguarding occupants' health and comfort.