Contribution of bone turnover markers to bone mass in pubertal boys and girls

Abstract

Background and aims:The association between bone turnover markers and bone mass in adolescence is not clear. We aimed to evaluate the associations between bone turnover markers and bone mineral content (BMC), density (BMD) and area (BMA). Subjects: A total of 56 adolescents (25 boys, 12.5 -17.5 years) participated in the study. Methods: Bone mass and physical activity (PA) were measured using dual energy X-ray absorptiometry and accelerometers. Osteocalcin and amino-terminal propeptide of type I procollagen (PINP), as markers of bone formation, and β -isomer of the C-terminal telopeptide of type I collagen, as marker of bone resorption were also measured. Sexual maturation, weight, height and average PA were considered as confounders. Results: Positive correlations (Pearson) were observed among the three bone turnover markers (r = 0.7 -0.9). Stepwise multiple linear regression analyses showed that PINP was strong and negatively associated with BMC, BMD and BMA in girls, explaining 24.9 % of the variance in BMC, 25.6 % in BMD and 16.3 % in BMA. Conclusion: PINP is a strong predictor of bone related variables in pubertal girls.

Association of Lean and Fat Body Mass, Bone Biomarkers and Gonadal Steroids with Bone Mass during Pre- and Midpuberty

“…Moreover, the high levels of estradiol inhibit chondrocyte proliferation and play a role in the decline of both height velocity and bone turnover [24]. Other studies have proved the negative influences of procollagen type-1 N-terminal propeptide on bone mass in pubertal girls [25]. The decline of the levels of bone turnover markers also begins earlier in girls [26], and the negative effect on bone mass in girls.…”

Metabolismo óseo en población infantil y adolescente deportista: revisión sistemática

“…Por otro lado, García-Marco y cols. (50), en otro estudio en población general adolescente (edades entre 12 y 17 años), determinaron una disminución de los marcadores conforme avanzaba la pubertad, tanto en chicos como en chicas. Relacionado con lo anterior, Slemenda y cols.…”

“…Slemenda et al (44) indican que concentraciones bajas de los marcadores durante el desarrollo del pico de MO aumentan los valores de DMO en esta etapa. Por otra parte, se ha determinado un dimorfismo sexual óseo, siendo mayor y más duradero el proceso de remodelado óseo en los chicos respecto a las chicas durante la adolescencia, aspecto beneficioso en tér-minos de ganancia ósea neta en los varones (50).…”

“…En deportes catalogados como osteogénicos (de alto impacto), es decir, aquellos en los que existe presencia de gravedad e impacto sobre el suelo (53), sí que se han encontrado algunas diferencias al comparar a gimnastas rítmicas con nadadoras, donde las primeras presentaron valores más altos en el marcador de formación OC (45). Sin embargo, parece ser que deportes no osteogénicos (de bajo impacto) (53) como la natación no provocan efectos sobre los marcadores, ya que no se han encontrado diferencias entre nadadores y grupo control (50,51).…”

Low bone mineral density in patients with Sickle Cell Anaemia (SCA) and short stature should be interpreted with caution

“…Evidently, all these factors could exert a strong influence upon acquisition of bone mass, which is also a quite complex process, and, above all, is strongly influenced by genetic background. The most rapid gains in bone mass are observed during adolescence, especially between 11 and 14 years in normal girls and 14 and 16 years in boys, with as much as 51% of peak bone mass accumulating during pubertal growth and reaching 37% of adults bone mass or of the bone mass that we will have as adults (Gracia-Marco et al 2010). Puberty in patients with SCA is delayed and arrested, and we must consider that their acquisition of mineral content will also be delayed; yet, a high percentage of patients usually do not reach a low/ normal BMD value.…”