Contribution of budesonide nebulization in bronchoscopy

Abstract

Background To investigate the efficacy and safety of budesonide nebulization for pre-examination preparation of bronchoscopy under topical anesthesia.Methods Patients with airway topical anesthesia by bronchoscopy were randomly divided into observation group and control group. Observation group was administrated with nebulization of budesonide combined with lidocaine whereas patients in control group were treated with lidocaine into same volume of sterile water. Visual analogue scale (VAS) and Wong-Baker FACES Pain Rating Scale (FPS-R) were utilized to assess cough, degree of pain, willingness to accept reinspection, and the satisfactions of operator towards patient cooperation. Additionally, the duration of examination, lidocaine consumption, and type of examination were recorded throughout our study.Results Compared with the controls, observation group showed a lower maximum systolic blood pressure and diastolic blood pressure together with extent of cough and pain whereas higher minimum transcutaneous oxygen saturation and satisfaction to the cooperation. Also, the observation group consumed shorter operation time, less lidocaine dosage, with less budesonide-related adverse reactions. Notably, there was no statistically significance in general condition, willingness to reinspection, type of operation, and diagnostic condition between two groups.Conclusion Taken aforementioned results together, topical anesthesia combined with budesonide suggests to be more optimal for airway preparation before bronchoscopy.Trial registration The trial was registered at Chinese Clinical Trial Registry No ChiCTR2300069170