Contribution of chemical permeation enhancers to the process of transdermal drug delivery: Adsorption, microscopic interactions, and mechanism

Jiang, Zhaoli; Liu, Shasha; Zhang, Heng; Li, Ying; Yuan, Shiling

doi:10.1016/j.colsurfb.2024.114138

Colloids and Surfaces B: Biointerfaces

2024

DOI: 10.1016/j.colsurfb.2024.114138

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Contribution of chemical permeation enhancers to the process of transdermal drug delivery: Adsorption, microscopic interactions, and mechanism

Zhaoli Jiang,

Shasha Liu,

Heng Zhang

et al.

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2024

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Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review

Wang,

Yang,

Zhang

et al. 2024

Front. Nutr.

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Bioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to their widespread use in the food and pharmaceutical industries. This article reviews the key factors influencing the absorption efficiency of oral bioactive peptides, including issues related to bitter taste perception, challenges in gastrointestinal environmental stability, and limitations in transmembrane transport. Furthermore, it highlights the latest technologies, such as osmotic technology, chemical modification, and advanced delivery systems, and discusses their advantages in enhancing the stability of bioactive peptides and facilitating intestinal absorption. In addition, the application and challenges of common delivery systems such as liposomes, emulsions, polymer nanoparticles, and hydrogels in oral bioactive peptide delivery are also discussed. This paper aims to provide a theoretical foundation for scientific research and practical applications of oral delivery of bioactive peptides, thereby promoting the further development of bioactive peptides in the context of human health.

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Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review

Wang,

Yang,

Zhang

et al. 2024

Front. Nutr.

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show abstract

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Contribution of chemical permeation enhancers to the process of transdermal drug delivery: Adsorption, microscopic interactions, and mechanism

Cited by 1 publication

References 63 publications

Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review

Obstacles, research progress, and prospects of oral delivery of bioactive peptides: a comprehensive review

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