The frequent occurrence of dry and hot (DH) days in South China in summer has a negative impact on social development and human health. This study explored the variation characteristics of DH days and the possible reasons for this knotty problem. The findings revealed a notable increase in the number of DH days across most stations, indicating a significant upward trend. Additionally, DH events were observed to occur frequently. The number of DH days increased during 1970-1990, decreased from 1991 to 1997, and stayed stable after 1997. The key climate factors affecting the interannual variability of the number of DH days were the Indian Ocean Basin warming (IOBW) in spring and the East Asian Summer Monsoon (EASM). Compared with the negative phase of IOBW, in the positive phase of IOBW, 500 hPa and 850 hPa geopotential height enhanced, the West Pacific subtropical high strengthened and extended abnormally to the west, more solar radiation reached the surface, surface outgoing longwave radiation increased, and there was an anomalous anticyclone in eastern South China. The atmospheric circulation characteristics of the positive and negative phases of ESAM were opposite to those of IOBW, and the abnormal circulation of the positive (negative) phases of ESAM was unfavorable (favorable) for the increase in the number of DH days. A long-term prediction model for the number of summer DH days was established using multiple linear regression, incorporating the key climate factors. The correlation coefficient between the observed and predicted number of DH days was 0.65, and the root-mean-square error was 2.8. In addition, independent forecasts for 2019 showed a deviation of just 1 day. The results of the independent recovery test confirmed the stability of the model, providing evidence that climatic factors did have an impact on DH days in South China.