Contribution of different calcium channels to long-term potentiation in superior cervical ganglion of the rat

Cifuentes, Fredi; Licona, Ileana; León, Losey; Medina, Patricia Mora; De‐Miguel, Francisco F.; Morales, M.A.

doi:10.1016/j.neuroscience.2004.08.038

Cited by 15 publications

(11 citation statements)

References 42 publications

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“…The significance of this result has since been contested. Firstly, roscovitine may enhance P/Q-type VDCC conductance in a Cdk5-independent manner, which is of importance as these channels are themselves implicated in LTP (Yan et al 2002;Cifuentes et al 2004). Secondly, a recent study was unable to reproduce these data.…”

Section: Short-term Plasticitymentioning

confidence: 98%

Cyclin‐dependent kinase 5 in synaptic plasticity, learning and memory

Angelo

Plattner

Giese

2006

Journal of Neurochemistry

124

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Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase with a multitude of functions. Although Cdk5 is widely expressed, it has been studied most extensively in neurons. Since its initial characterization, the fundamental contribution of Cdk5 to an impressive range of neuronal processes has become clear. These phenomena include neural development, dopaminergic function and neurodegeneration. Data from different fields have recently converged to provide evidence for the participation of Cdk5 in synaptic plasticity, learning and memory. In this review, we consider recent data implicating Cdk5 in molecular and cellular mechanisms underlying synaptic plasticity. We relate these findings to its emerging role in learning and memory. Particular attention is paid to the activation of Cdk5 by p25, which enhances hippocampal synaptic plasticity and memory, and suggests formation of p25 as a physiological process regulating synaptic plasticity and memory.

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Section: Short-term Plasticitymentioning

confidence: 98%

Cyclin‐dependent kinase 5 in synaptic plasticity, learning and memory

Angelo

Plattner

Giese

2006

Journal of Neurochemistry

124

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“…As mentioned earlier, we have previously proposed that LTP occurs mainly because a noncholinergic cotransmitter is released from LDCV (Bachoo et al, 1992;Morales et al, 1993;Collier, 1996;Cifuentes et al, 2004). This cotransmitter acting postsynaptically would be the basis for LTP.…”

Section: Intracellular Ca 2+ Release Contributes To Exocytosis Of a Nmentioning

confidence: 80%

“…Accordingly, Peng (1996) found that high frequency stimulation, which produces LTP, induced an increase of Ca 2þ entry, and after the triggering of CICR, Ca 2þ reached a threshold sufficient to permit the release of luteinizing hormone releasing hormone from large dense core vesicles (LDCV) in bullfrog sympathetic ganglia. Likewise, we have proposed that an accumulation of intracellular Ca 2þ , sufficient to cause the release of noncholinergic cotransmitters from LDCVs, can induce LTP (Cifuentes et al, 2004). The enhancement of LTP at high extracellular Ca 2þ concentrations is probably because the conditioning train keeps the VOCC open for longer times.…”

Section: Contribution Of Extracellular Ca 2þ To Basal Ganglionic Tranmentioning

confidence: 95%

“…In the autonomic nervous system, as in the central nervous system, Ca 2þ plays an important role in several neuronal functions including basal ganglionic transmission and synaptic facilitation such as ganglionic long-term potentiation (LTP). This phenomenon is characterized by a long-lasting increase in ganglionic synaptic transmission induced by the application of a brief train of high frequency stimulation (Dunant and Dolivo, 1968;Brown and McAfee, 1982;Briggs et al, 1985;Briggs and McAffe, 1988;Alonso-deFlorida et al, 1991;Cifuentes et al, 2004;Alkadhi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In sympathetic ganglia, Ca 2þ entry through VOCCs contributes both to basal transmission and to LTP (Gonzalez-Burgos et al, 1995;Cifuentes et al, 2004). Calcium release from intracellular sources is important in both facilitation and LTP of bullfrog ganglia (Peng, 1996;Cong et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Differential contribution of extracellular and intracellular calcium sources to basal transmission and long‐term potentiation in the sympathetic ganglion of the rat

Vargas

Cifuentes

Morales

2007

Developmental Neurobiology

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Calcium involved in basal ganglionic transmission and long-term potentiation (LTP) can arise either by influx from the extracellular medium or release from intracellular stores. No attempts have yet been made to concurrently explore the contributions of extracellular and intracellular Ca2+ to basal ganglionic transmission or LTP. Here, we investigate this subject using the superior cervical ganglion of the rat. To explore the extracellular Ca2+ contribution, we evaluated basal transmission and LTP at different extracellular Ca2+ concentrations. To assess intracellular Ca2+ release, we explored the contribution of the calcium-induced calcium release process by overactivation or blockade of ryanodine-sensitive Ca2+ receptor channel with caffeine, and also by blocking either IP3R with Xestospongin C or the sarco(endo)plasmic reticulum Ca2+-ATPase pump with thapsigargin. Extracellular Ca2+ affected ganglionic basal transmission and LTP to different extents. While 25% of the physiological Ca2+ concentration supported 80% of basal transmission, 50% of normal Ca2+ was required to achieve 80% of LTP. Notably, disruption of intracellular Ca2+ release by all the drugs tested apparently did not affect basal ganglionic transmission but impaired LTP. We conclude that basal transmission requires only a small level of Ca2+ entry, while LTP expression not only requires more Ca2+ entry but is also dependent on Ca2+ release from intracellular stores.

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Neuronal L‐Type Voltage‐Gated Calcium Channels

Scriabine

Triggle

2008

Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

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Contribution of different calcium channels to long-term potentiation in superior cervical ganglion of the rat

Cited by 15 publications

References 42 publications

Cyclin‐dependent kinase 5 in synaptic plasticity, learning and memory

Cyclin‐dependent kinase 5 in synaptic plasticity, learning and memory

Differential contribution of extracellular and intracellular calcium sources to basal transmission and long‐term potentiation in the sympathetic ganglion of the rat

Neuronal L‐Type Voltage‐Gated Calcium Channels

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