Contribution of Donor and Recipient Characteristics to Short- And Long-Term Pancreas Graft Survival

Solitary pancreas transplantation: a review of the UK experience over a period of 10 yr

“…This result should be interpreted with caution given the small number of BMI > 30 donors. However, it concords with previous studies and highlights the fact that pancreata from high BMI donors should not be precluded from transplantation. Visualization of the pancreas in vivo by an experienced transplant surgeon, as mandated by the UK regulatory body, may be an important factor that can in turn encourage a relatively rapid retrieval process and transplantation to reduce the CIT.…”

HLA-A, -B, -C, -DR, and -DQ Matching in Pancreas Transplantation: Effect on Graft Rejection and Survival

“…Likewise, a study published that same year involving > 1000 pancreas recipients from earlier eras at our institution showed no difference in graft survival for SPK recipients with HLA-A or -B matching, but did note a trend toward significance with HLA-DR matching (19). Even more recently, multiple studies have shown no difference in graft survival with overall HLA matching when comparing a high number of MMs versus a low number or none (20)(21)(22)(23)(24)(25). Nonetheless, despite no increase in early graft loss, an increased number of MMs does appear to be associated with an increased AR rate (20,21,25).…”

Sex matching does not impact the outcome after simultaneous pancreas‐kidney transplantation

“…In addition, the male donor to female recipient pairing had the best long‐term kidney and pancreatic graft function. Hilling et al focused on the contribution of donor and recipient characteristics to outcomes after pancreas transplantation in a retrospective single‐center analysis (n = 170); factors significantly influencing PGS were female recipient sex and enteric graft drainage as well as donor‐recipient match on BMI.…”

“…It has also been postulated that estrogen and testosterone levels and their impact on ischemia/reperfusion injury as well as immunologic factors such as the H‐Y antigen may play a role in this context . The importance of sex matching has been investigated in the setting of pancreas transplantation; however, only few reports address the impact of recipient and donor sex as well as sex matching on the outcome after pancreas transplantation . A large US registry study recently reported that sex matching significantly decreased the risk for pancreas graft failure .…”