Abbreviations: TOVA, test of variables of attention; MMPI, minnesota multiphasic personality inventory; cAMP, cyclic adenosine monophosphate; CREB, camp response element binding protein; MCI, mild cognitive impairment
Introduction Recognizing addiction as a public health crisisA recent report published by the Center for Behavioral Health Statistics and Quality found that approximately one in seven Americans is expected to develop a substance use disorder at some point in their lives.1 In 2015, 20.8 million people aged 12 or older in the United States had a substance abuse disorder, indicating that the number of Americans suffering from addiction is similar to the number of Americans suffering from diabetes.2 Moreover, the prevalence of substance use disorders is nearly 1.5 times that of all cancers combined.
3In 2014, over 47,000 people died from a drug overdose. This figure includes nearly 30,000 people who died from an overdose involving prescription drugs, which is more than in any previous year on record. Heroin overdoses have more than tripled between 2010 and 2014. 4 Alcohol misuse, which contributes to 88,000 deaths per year in the United States, was found to be the nation's fourth leading preventable cause of death. 5,6 Approximately one in ten deaths among working adults in the United States is caused by alcohol abuse. 5 The health care expenses, lost productivity, and criminal justice costs related to substance abuse are estimated to cost the federal government $442 billion dollars each year. 7,8 In response to this public health crisis, the U.S. Surgeon General published a report declaring that addiction must be approached as a chronic illness, alongside conditions such as heart disease, diabetes, and cancer.
Current issues in addiction treatment and relapse preventionAddiction is characterized by improper engagement of the systems involved in adaptive decision-making.10 Deficiencies in executive functions such as working memory allow substance use behavior to be guided more strongly by automatic, impulsive processes.11 Genetic polymorphisms or stress may induce a hypodopaminergic trait/state, predisposing individuals to instinctively seek out substances or behaviors that stimulate dopaminergic activity.12,13 Substance use may thus engage a vicious cycle, as addictive drugs have been implicated to damage brain regions involved in higher-order functioning, further reducing self-regulatory capabilities.14 Although traditional methodologies such as counseling, group therapy, and medication have produced some success in treating addiction, relapse rates remain high. Bailey et al. reported that 90% of inpatient opioid detoxification patients relapsed within a year of treatment.15 A key factor accounting for the likelihood of relapse among addiction patients may be the persistence of aberrant neurobiological changes affecting reward prediction and motivation. It is plausible that traditional therapies may only address maladaptive patterns of synaptic connectivity to a limited extent, preserving some aberra...