Contribution of exhaled nitric oxide measurement in airway inflammation assessment in asthma. A position paper from the French Speaking Respiratory Society

Dinh-Xuan, Anh Tuan; Annesi‐Maesano, Isabella; Berger, Patrick; Chambellan, Arnaud; Chanez, Pascal; Chinet, Thierry; Degano, Bruno; Delclaux, Christophe; Demange,; Didier, A.; Garcia, Gilles; Magnan, A.; Mahut, Bruno; Roche, N.

doi:10.1016/j.rmr.2014.11.004

Cited by 29 publications

(25 citation statements)

References 88 publications

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“…These reports align with our finding that baseline and delayed‐phase FeNO levels were higher in allergic rhinitis with AHR than without AHR. The increase in FeNO associated with sputum eosinophilia in asthma had been demonstrated . Our result further showed that an increase in FeNO is associated with sputum eosinophilia in allergic rhinitis.…”

Section: Discussionsupporting

confidence: 84%

Aggravation of airway inflammation and hyper‐responsiveness following nasal challenge with Dermatophagoides pteronyssinus in perennial allergic rhinitis without symptoms of asthma

Xian

Xie

et al. 2015

Allergy

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Section: Discussionsupporting

confidence: 84%

Aggravation of airway inflammation and hyper‐responsiveness following nasal challenge with Dermatophagoides pteronyssinus in perennial allergic rhinitis without symptoms of asthma

Xian

Xie

et al. 2015

Allergy

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“…The use of nasal FENO in diagnosis of AR has been reported in previous studies 13,17. Similar to other allergic inflammatory airway diseases such as asthma, in AR, the increase in nasal FENO appears to be related to the upregulation of inducible NO synthase, mainly in epithelial cells and eosinophils 19–22…”

Section: Discussionmentioning

confidence: 90%

Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma

Duong‐Quy

Vu-Minh²,

Hua-Huy

et al. 2017

JAA

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“…Asthma severity was evaluated according to GINA guidelines, and the level of asthma control was assessed by a selfadministered questionnaire, the Asthma Control Test (ACT) [16]. Airway eosinophilic inflammation was estimated by measuring exhaled nitric oxide [17]. Values >25 ppb were considered to be abnormal.…”

Section: Respiratory Assessmentmentioning

confidence: 99%

Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature

Seccia

Baldini

Latorre

et al. 2018

Int Arch Allergy Immunol

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Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing vasculitis that predominantly affects small- to medium-sized vessels. It is characterized by a wide spectrum of extrapulmonary symptoms, including sinonasal and paranasal sinus abnormalities. These are the most common features of this disease, constituting diagnostic criteria for EGPA. However, the actual clinical features, cellular mechanisms and impact on patients’ quality of life (QoL) are still a matter of study. Methods: Thirty-nine EGPA patients underwent multidimensional rhinological evaluations, including rhinofibroscopy, nasal cytology, and QoL questionnaires. This was coupled with respiratory and rheumatological assessments. Results: Twenty-eight patients were diagnosed with chronic rhinosinusitis (CRS). Of these, 18 had nasal polyposis (NP). Chronic rhinitis was diagnosed in 10 patients. Of these, 3 had allergic rhinitis (AR) and seven had non-AR (NAR). Overall, only 1 patient (2.6%) was normal. Nasal cytology showed that hypereosinophilia was present in 17/28 patients with CRS, 4/7 patients with NAR and all patients with AR. SNOT-22 and SF-36 showed a severe impact of nasal symptoms on QoL. No differences in asthma control or rheumatological patterns for EGPA were observed among patients with or without NP. Conclusions: Even when the rheumatological assessment scored EGPA “under control” according to the Birmingham Vasculitis Activity Score and Vasculitis Damage Index, sinonasal diseases and related nasal inflammatory processes were not controlled. Therefore, there is a need for clinical monitoring and targeted treatment to control the inflammatory processes and improve the QoL of EGPA patients.

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Contribution of exhaled nitric oxide measurement in airway inflammation assessment in asthma. A position paper from the French Speaking Respiratory Society

Cited by 29 publications

References 88 publications

Aggravation of airway inflammation and hyper‐responsiveness following nasal challenge with Dermatophagoides pteronyssinus in perennial allergic rhinitis without symptoms of asthma

Aggravation of airway inflammation and hyper‐responsiveness following nasal challenge with Dermatophagoides pteronyssinus in perennial allergic rhinitis without symptoms of asthma

Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma

Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature

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