Contribution of Extra-cerebral and Cerebral Hemodynamic Signals During Exercise Quantified with Time-domain Near Infrared Spectroscopy

Auger, Héloïse; Bherer, Louis; Boucher, Étienne; Hoge, Richard D.; Lesage, Frédéric; Dehaes, Mathieu

doi:10.1364/cancer.2016.jw3a.22

Cited by 3 publications

(9 citation statements)

References 6 publications

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“…The copyright holder for this preprint this version posted August 16, 2022. ; https://doi.org/10.1101/2022.08.14.22278765 doi: medRxiv preprint infrared spectroscopy (NIRS). NIRS allows for a non-invasive, non-ionizing, low-cost, and practical evaluation of cerebrovascular responses and tissue oxygenation to exercise (Andrianopoulos et al, 2018;Auger et al, 2016). NIRS relies on near-infrared light (700-1000 nm) to permeate skin, bone, and muscle (Simonson & Piantidosi, 1996).…”

Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

“…NIRS relies on near-infrared light (700-1000 nm) to permeate skin, bone, and muscle (Simonson & Piantidosi, 1996). Continuouswave NIRS measures changes in relative oxy-and deoxy-hemoglobin concentrations resulting from neural activity (Auger et al, 2016). Although NIRS signal is not an absolute measure of regional blood flow and can be influenced by skin vasculature signals (Auger et al, 2016;Matsukawa et al, 2015), it has the advantage of high temporal resolution while being portable and non-invasive (Shibuya et al, 2004).…”

Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

“…Positron emission tomography (PET) is another common alternative, as it allows for a quantitative measure of global and regional CBF (Auger et al, 2016) due to its relatively high spatial resolution (Hiura et al, 2013). PET allows for measuring brain metabolism by exploring the distribution of previously injected contrast radioactive agents (Auger et al, 2016). However, the use of radioactive contrast agents makes PET a less popular option for investigating CBF in research compared to other CBF measurement techniques.…”

Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

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Effect of acute cardiovascular exercise on cerebral blood flow: A systematic review

Mulser

Moreau

2023

Brain Research

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Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

See 1 more Smart Citation

Effect of acute cardiovascular exercise on cerebral blood flow: A systematic review

Mulser

Moreau

2023

Brain Research

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Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

Section: Measuring Cerebral Blood Flowmentioning

confidence: 99%

Effect of Acute Cardiovascular Exercise on Cerebral Blood Flow: A Systematic Review

Mulser

Moreau

2022

Preprint

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A single bout of cardiovascular exercise can have a cascade of physiological effects, including increased blood flow to the brain. This effect has been documented across multiple modalities, yet studies have reported mixed findings. Here, we systematically review evidence for the acute effect of cardiovascular exercise on cerebral blood flow across a range of neuroimaging techniques and exercise characteristics. Based on 52 studies and a combined sample size of 1,174 individuals, our results indicate that the acute effect of cardiovascular exercise on cerebral blood flow generally follows an inverted U-shaped relationship, whereby blood flow increases early on but eventually decreases as exercise continues. However, we also find that this effect is not uniform across studies, instead varying across a number of key variables including exercise characteristics, brain regions, and neuroimaging modalities. As the most comprehensive synthesis on the topic to date, this systematic review sheds light on the determinants of exercise-induced change in cerebral blood flow, a necessary step toward personalized interventions targeting brain health across a range of populations.

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Dissociated coupling between cerebral oxygen metabolism and perfusion in the prefrontal cortex during exercise: a NIRS study

et al. 2023

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Purpose: The present study used near-infrared spectroscopy to investigate the relationships between cerebral oxygen metabolism and perfusion in the prefrontal cortex (PFC) during exercises of different intensities.Methods: A total of 12 recreationally active men (age 24 ± 6 years) were enrolled. They performed 17 min of low-intensity exercise (ExL), followed by 3 min of moderate-intensity exercise (ExM) at constant loads. Exercise intensities for ExL and ExM corresponded to 30% and 45% of the participants’ heart rate reserve, respectively. Cardiovascular and respiratory parameters were measured. We used near-infrared time-resolved spectroscopy (TRS) to measure the cerebral hemoglobin oxygen saturation (ScO2) and total hemoglobin concentration ([HbT]), which can indicate the cerebral blood volume (CBV). As the cerebral metabolic rate for oxygen (CMRO2) is calculated using cerebral blood flow (CBF) and ScO2, we assumed a constant power law relationship between CBF and CBV based on investigations by positron emission tomography (PET). We estimated the relative changes in CMRO2 (rCMRO2) and CBV (rCBV) from the baseline. During ExL and ExM, the rate of perceived exertion was monitored, and alterations in the subjects’ mood induced by exercise were evaluated using the Profile of Moods Scale-Brief.Results: Three minutes after exercise initiation, ScO2 decreased and rCMRO2 surpassed rCBV in the left PFC. When ExL changed to ExM, cardiovascular variables and the sense of effort increased concomitantly with an increase in [HbT] but not in ScO2, and the relationship between rCMRO2 and rCBV was dissociated in both sides of the PFC. Immediately after ExM, [HbT], and ScO2 increased, and the disassociation between rCMRO2 and rCBV was prominent in both sides of the PFC. While blood pressure decreased and a negative mood state was less prominent following ExM compared with that at rest, ScO2 decreased 15 min after exercise and rCMRO2 surpassed rCBV in the left PFC.Conclusion: Dissociated coupling between cerebral oxidative metabolism and perfusion in the PFC was consistent with the effort required for increased exercise intensity and associated with post-exercise hypotension and altered mood status after exercise. Our result demonstrates the first preliminary results dealing with the coupling between cerebral oxidative metabolism and perfusion in the PFC using TRS.

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Contribution of Extra-cerebral and Cerebral Hemodynamic Signals During Exercise Quantified with Time-domain Near Infrared Spectroscopy

Cited by 3 publications

References 6 publications

Effect of acute cardiovascular exercise on cerebral blood flow: A systematic review

Effect of acute cardiovascular exercise on cerebral blood flow: A systematic review

Effect of Acute Cardiovascular Exercise on Cerebral Blood Flow: A Systematic Review

Dissociated coupling between cerebral oxygen metabolism and perfusion in the prefrontal cortex during exercise: a NIRS study

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