CONTRIBUTION OF FRONTAL CEREBRAL BLOOD FLOW MEASURED BY 99mTc-BICISATE SPECT AND EXECUTIVE FUNCTION DEFICITS TO PREDICTING TREATMENT OUTCOME IN ALCOHOL-DEPENDENT PATIENTS

Noël, Xavier; Sferrazza, Rita; Linden, Martial Van der; Paternot, Jacques; Verhas, Michel; Hanak, Catherine; Pelc, Isidore; Verbanck, Paul

doi:10.1093/alcalc/37.4.347

Cited by 123 publications

(107 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly to Noël et al (2001Noël et al ( , 2002; see also Ratti et al 2002), we observed that ALC exhibited working memory abnormalities. The results of the alpha-span task show that ALC's ability to store information in working memory (measure the span size and the score of direct recall condition) remained normal, but the ability to manipulate the information stored (measured by the alphabetical recall condition) was impaired.…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

et al. 2007

View full text Add to dashboard Cite

Background Individuals with alcoholism are characterized by both attentional bias for alcohol cues and prepotent response inhibition deficit. We tested the hypothesis that alcoholics exhibit greater cognitive disinhibition when the response to be suppressed is associated with alcohol-related information. Methods Forty recently detoxified individuals with alcoholism were compared with 40 healthy non-substance abusers on the "Alcohol-Shifting Task", a variant of the go/no-go paradigm requiring a motor response to targets and no response to distracters. The aim was to test the ability of alcoholics to discriminate between alcohol-related and neutral words. Sometimes, the alcohol-related words were the targets for the "go" response, with neutral words as distracters, sometimes the reverse. Several shifts in target type occurred during the task. Results Alcoholics made significantly more commission errors (i.e., press a key when a distracter displayed) and more omission errors (i.e., not press a key when a target displayed) than controls. Moreover, the number of commission errors was greater in alcoholics when alcoholrelated stimuli had to be detected. Conclusions These results demonstrate that alcoholics exhibit a basic prepotent response inhibition deficit, which is enhanced when the response to be suppressed is related to alcohol. We discuss clinical and theoretical implications of these findings.

show abstract

Section: Discussionsupporting

confidence: 77%

“…Therefore, abnormal motivational properties of alcohol and/or impaired prepotent response inhibition may lead to loss of control of alcohol use and to alcohol relapse (Noël et al 2002;Cox et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Neuropathological observations demonstrated alcoholismrelated neuronal loss in prefrontal association-cortex, hypothalamus, and cerebellum (64,65). Frontal dysfunction in alcoholism has been demonstrated by neuropsychological investigations (66)(67)(68)(69)(70)(71) and by metabolic (20), cerebral blood flow (72,73), and functional MRI (74) studies. Brain structural changes become more prominent with aging (17,21,35), and alcoholism can exaggerate age-related volumetric reductions (75,76).…”

Section: Discussionmentioning

confidence: 99%

Decreased Volume of the Brain Reward System in Alcoholism

Makris

Oscar‐Berman

Jaffin

et al. 2008

Biological Psychiatry

345

327

View full text Add to dashboard Cite

Background-Reinforcement of behavioral responses involves a complex cerebral circuit engaging specific neuronal networks that are modulated by cortical oversight systems affiliated with emotion, memory, judgment, and decision making (collectively referred to in this study as the "extended reward and oversight system" or "reward-network"). We examined whether rewardnetwork brain volumes are reduced in alcoholics, and how volumes of subcomponents within this system are correlated with memory and drinking-history.

show abstract

“…Alcohol-dependence has been associated with memory compromise, a compromise that has been observed for working memory [1][2][3][4][5], for memory for verbal or nonverbal stimuli [6][7][8], and for source memory, i.e., the ability to remember the context in which an event occurred [9,10]. Interestingly, autobiographical memory, or memory for personal experiences, has been also found to be compromised in alcohol-dependence.…”

Section: Introductionmentioning

confidence: 99%

Flashbulb memories for Paris attacks in an alcohol-abstinent patient

Haj¹,

Gandolphe²

2017

J Syst Integr Neurosci

View full text Add to dashboard Cite

Alcohol-dependence has been associated with difficulty to retrieve specific autobiographical memories. Our paper investigated whether this difficulty is also observed for flashbulb memories in an alcohol-abstinent patient. Using a directed interview technique, we assessed flashbulb memories for the Paris attacks in a patient who had been abstinent for two years. Our patient demonstrated reliable recall of event memory (i.e., the attacks). He also provided fair details about how he first became aware of the attacks (i.e., high flashbulb memories). Our patient also succeeded to answer questions about where he was, with who he was, and what day of the week/ time it was when he first learned about the attacks. Moreover, the patient demonstrated fair subjective reliving. Together, flashbulb memories seem to trigger high recall as well as extensive reliving in alcohol-abstinent subjects, at least in our participant.

show abstract

CONTRIBUTION OF FRONTAL CEREBRAL BLOOD FLOW MEASURED BY 99mTc-BICISATE SPECT AND EXECUTIVE FUNCTION DEFICITS TO PREDICTING TREATMENT OUTCOME IN ALCOHOL-DEPENDENT PATIENTS

Abstract: Inhibition and working memory deficits, associated with low levels of CBF in the medial frontal gyrus, are related to the difficulty of maintaining short-term abstinence from alcohol.

Cited by 123 publications

References 58 publications

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

Decreased Volume of the Brain Reward System in Alcoholism

Flashbulb memories for Paris attacks in an alcohol-abstinent patient

Contact Info

Product

Resources

About