Contribution of hemodynamic disturbances in magistral vessels to optic neuropathy progression and ocular tension changes in endocrine ophthalmopathy

Лихванцева, В.Г.; Kharlap, S I; Korosteleva, E. V.; Соломатина, М. В.; Melnikova, M. V.; Budanova, S V; Regeb, A Ben; Выгодин, В А

doi:10.17116/oftalma2015131432-37

Cited by 6 publications

(4 citation statements)

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“…Changes in orbital blood flow in patients with TED have been reported in previous studies ( 9 – 11 , 22 – 24 ). Using color Doppler sonography, Somer et al ( 23 ) reported lower mean superior ophthalmic vein blood flow velocity in patients with TED compared with those without TED.…”

Section: Discussionsupporting

confidence: 77%

Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Tsai

Chu

et al. 2022

BioMed Research International

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Background. Laser speckle flowgraphy (LSFG) can be used to estimate optic nerve blood flow. This study used LSFG to evaluate optic nerve microcirculation in patients with thyroid eye disease (TED). Methods. This was a retrospective review of patients with active TED who underwent LSFG between October 2020 and June 2021. The mean blur rate (MBR) for different severities of active TED was analyzed by one-way analysis of variance (ANOVA). Results. A total of 30 patients (60 eyes) with a diagnosis of active TED who underwent LSFG were included. The mean age was 49 (range, 33–74) years. Mean best-corrected visual acuity was the worst in the group with sight-threatening active TED ( 0.29 ± 0.33 logarithm of the minimum angle of resolution, p = 0.01 ). The MBR-overall was the highest in the group with mild active TED ( 28.5 ± 2.7 ), followed by that in the moderate to severe ( 23.6 ± 3.2 ), and in the sight-threatening ( 20.2 ± 4.3 ) active TED groups ( p < 0.001 ). The MBR-vessel was 57.1, 47.0, and 39.3 in the mild, moderate to severe, and sight-threatening active TED groups, respectively ( p < 0.001 ). The MBR-tissue was 16.9, 14.4, and 12.0 in the mild, moderate to severe, and sight-threatening active TED groups, respectively ( p < 0.001 ). Conclusions. This study demonstrates that optic nerve blood flow is lower with more severe active TED. In addition, LSFG is an effective, objective, and noninvasive method for evaluating the severity of TED.

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Section: Discussionsupporting

confidence: 77%

Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Tsai

Chu

et al. 2022

BioMed Research International

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“…При этом лишь единичные работы посвящены анализу кровотока в a. Ophthalmica, a. et v. Retinae centralis, a. Ciliaris posterior brevis et longae на фоне первичного нелеченого тиреотоксикоза и гипотиреоза. В представленных публикациях внимание исследователей сконцентрировано на доплерографических параметрах, характеризующих скоростные показатели кровотока, не отражающие в пол-ной мере глубину ишемии органа зрения, в частности, его переднего отдела [4,5]. Между тем именно ишемия преэкваториального отдела определяет гидродинамику глаза и чувствительность зрительного анализатора к любым патогенным механизмам, включая ишемический фактор [6].…”

Section: Ischemia Of the Eye On The Background Of Primaryunclassified

“…Собственно, это заключение подтверждают представленные выше показатели ПОКа, МОКа и МОКv. Результаты плетизмографии подтверждают, что даже при отсутствии эндокринной офтальмопатии у больных с ПГТ и ПТТ развиваются глубокие гемодинамические нарушения в магистральных сосудах глаза [5]. Это приводит к ишемии переднего и заднего отделов глаза, что может повлечь за собой гидродинамические нарушения, повысить чувствительность зрительного анализатора к ишемии и гипоксии и способствовать развитию вторичной оптической нейропатии.…”

Section: результаты и обсуждениеunclassified

Ischemia of the Eye on the Background of Primary Hypothyroidism and Primary Thyrotoxicosis

Лихванцева

Коростелёва

2019

Oftalʹmologiâ

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Purpose: to study the features of the blood filling of the eye in patients with primary untreated hypothyroidism and primary untreated thyrotoxicosis by plethysmography. Materials and methods. The material of the study was the results of a comprehensive examination of 43 patients (86 eyes): 23 people (46 eyes) with primary untreated hypothyroidism and 20 people (40 eyes) with primary untreated hyperthyroidism. The ocular blood flow was assessed by ophthalmoplethysmography. Results. The obtained plethysmography data confirm that even in the absence of endocrine ophthalmopathy in patients with primary untreated hypothyroidism and primary untreated thyrotoxicosis, deep hemodynamic disturbances in the major vessels of the eye develop leading to ischemia of its anterior and posterior parts, which can lead to hydrodynamic disturbances in the eye, sensitivity of the visual analyzer to ischemia and hypoxia and to promote the development of secondary optic neuropathy. In this study, a significant reduction of 30–40 % from the norm of volume and consumption indicators of the blood filling of the eye with impaired placement of blood in the choriocapillaries, reduced elasticity of the choroidal vessel wall was detected, which can not but trigger the development of various pathological processes. For example, ischemia of the ciliary body and the trabecular meshwork, the presence of thyroid receptors on endothelial and smooth muscle cells of choroidal and orbital vessels, can lead to hydrodynamic disturbances, and ischemia of the optic nerve, which arises due to violation peripapillary flow having choroidal source of blood supply, can result in an optical neuropathy. In this aspect, thyroid disease is associated with an increased risk of developing glaucoma, endocrine ophthalmopathy. The conclusion. Despite the constant expansion of various innovative dopplerographic systems, plethysmography — as a method of examining the blood filling of the eye, remains in demand, reliable and highly informative. In patients with uncompensated thyroid dysfunctions, a violation of the blood supply to the anterior segment of the eye is observed, which can cause a low effect of antihypertensive monotherapy in the treatment of glaucoma.

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“…Появились работы, свидетельствующие о по-вышении внутриглазного тонуса при тиреоидной дисфункции. Для объяснения этого факта одни авторы указывают на затруднение оттока водянистой влаги в трабекулярной сети [9][10][11], другие полагают, что повышается секреция водянистой влаги [9,12].…”

Section: Introductionunclassified

Features of the Eye Hydrodynamics on the Background of Thyroid Dysfunctions

et al. 2020

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Purpose: to study the features of eye hydrodynamics in patients with thyroid dysfunctions.Patients and methods. The material for this study was the results of a survey of 43 patients (86 eyes) with thyroid dysfunctions: 23 people (46 eyes) with primary untreated hypothyroidism (PGT) and 20 people (40 eyes) with primary untreated thyrotoxicosis (PTT). There weren’t ophthalmic hypertension and glaucoma There weren’t signs of ophthalmic hypertension and glaucoma in the patients included in this study at the stage of primary ophthalmologic diagnostics.Results. Correlation analysis revealed a causal relationship between the ratio of T4 / TSH hormones, on the one hand, and indicators of secretion of aqueous humor per unit of time and ease of outflow, on the other hand. In the group of patients with hypothyroidism, a weak linear inverse correlation was found between the ratio of free thyroxine and thyroid stimulating hormone and the minute volume of aqueous humor: according to the regression model, an increase in the ratio of T4 / TSH hormones by 1 was accompanied by a decrease in the minute volume of aqueous humor by 3 units. In patients with thyrotoxicosis, a statistically significant inverse linear correlation was found between the ratio of the T4 / TSH hormones and the coefficient of ease of outflow. According to the regression model, with an increase in the ratio of hormones T4 / TSH by 1, the coefficient of lightness of outflow decreases by 5 units. The presence of thyroid receptors in the cytoplasm and nuclei of the endothelium cells of the trabecular apparatus, the nuclei of fibroblasts forming the stroma of the trabeculae, as well as in the nuclei of the pigment and non-pigment epithelium of the processes of the ciliary body substantiates the molecular basis of the causal connection of thyroid dysfunctions with hydrodynamic disorders The conducted studies confirm the modern concept that the control of regulation of the tissue and organ homeostasis is carried out by the coordinated interaction of 3 systems: nervous, endocrine, and immune. Regression modeling clearly shows a pronounced causal relationship between thyroid dysfunctions and hydrodynamic processes in the eye.Conclusion. The results of clinical studies demonstrate the fact of controlling regulation by hydrodynamic processes at the eye level by the endocrine system, explain the possible mechanism on a morphological basis, and reveal the potential of a new therapeutic strategy.

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Contribution of hemodynamic disturbances in magistral vessels to optic neuropathy progression and ocular tension changes in endocrine ophthalmopathy

Cited by 6 publications

References 10 publications

Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Evaluation of Microcirculation in Optic Nerve Head Using Laser Speckle Flowgraphy in Active Thyroid Eye Disease

Ischemia of the Eye on the Background of Primary Hypothyroidism and Primary Thyrotoxicosis

Features of the Eye Hydrodynamics on the Background of Thyroid Dysfunctions

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