Contribution of Interleukin-12A Genotypes to Breast Cancer Risk

Wang, Yun-Chi; Wang, Zhihong; Shen, Te Chun; Chang, Wen-Shin; Huang, Si-Zein; Yu, Chien‐Chih; Chen, Jaw-Chyun; Hsiau, Yu-Chen; Yang, Jai Sing; Tsai, Chia-Wen; Bau, Da‐Tian

doi:10.21873/anticanres.15243

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…Moreover, BC in Taiwan is characterized by a marked surge in p alence and relatively early onset (diagnosis at 45-49 years) [6,8]. Our findings pro evidence suggesting that MTHFR genotypes might contribute to BC susceptibility an tentially play a role in the early onset of BC in Taiwan, aligning with alternative hyp ses proposed by other research groups [9][10][11][12]. Currently, one of the focal points for t lational scientists is the search for practical biomarkers for BC, particularly TNBC in wan [13][14][15].…”

Section: Introductionsupporting

confidence: 83%

“…A total of 1232 patients diagnosed with BC were enrolled from the outpatient clinics of the general surgery department at China Medical University Hospital in Taiwan for Life 2024, 14, 9 3 of 12 this study. All participants were of Taiwanese descent, and the detailed procedures, exclusion and inclusion criteria were previously documented [28][29][30]. Clinical characteristics, including histological details, were defined by Dr. Su and his team.…”

Section: Bc and Non-bc Control Populationmentioning

confidence: 99%

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The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan

Wang,

He,

Tsai

et al. 2023

Life

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Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinase-2 and is highly expressed in breast cancer (BC) cases at diagnosis. However, the genetic investigations for the association of TIMP-2 genotypes with BC risk are rather limited. In this study, contribution of TIMP-2 rs8179090, rs4789936, rs2009196 and rs7342880 genotypes to BC risk was examined among Taiwan’s BC population. TIMP-2 genotypic profiles were revealed among 1232 BC cases and 1232 controls about their contribution to BC using a PCR-based RFLP methodology. The TIMP-2 rs8179090 homozygous variant CC genotype was significantly higher in BC cases than controls (odds ratio (OR) = 2.76, 95% confidence interval (95%CI) = 1.78–4.28, p = 0.0001). Allelic analysis showed that C allele carriers have increased risk for BC (OR = 1.39, 95%CI = 1.20–1.62, p = 0.0001). Genotypic together with allelic analysis showed that TIMP-2 rs4789936, rs2009196 or rs7342880 were not associated with BC risk. Stratification analysis showed that TIMP-2 rs8179090 genotypes were significantly associated with BC risk among younger (≤55) aged women, not among those of an elder (>55) age. Last, rs8179090 genotypes were also associated with triple negative BC. This study sheds light into the etiology of BC in Taiwanese women. Rs8179090 may be incorporated into polygenic risk scores and risk prediction models, which could aid in stratifying individuals for targeted breast cancer screening.

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Section: Introductionsupporting

confidence: 83%

Section: Bc and Non-bc Control Populationmentioning

confidence: 99%

The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan

Wang,

He,

Tsai

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

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“…The same number of healthy subjects was recruited from the Health Examination Cohort. The participants are all Taiwanese and the detailed procedure has been previously published (12,46). Among all the breast cancer cases, 194 were identified as TNBC cases.…”

Section: Methodsmentioning

confidence: 99%

The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan

et al. 2022

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Background/Aim: Triple negative breast cancer (TNBC) is one of the most challenging breast cancer types. is a pro-tumorigenic cytokine, promoting tumor proliferation and migration. This study aimed to examine the contribution of IL-8 rs4073 genotypes to breast cancer risk and provide a summary of related literature. Materials and Methods: IL-8 genotypic profiles were determined among 1,232 breast cancer cases and 1,232 controls via polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The IL-8 rs4073 AT and AA genotypes had significantly lower prevalence in the case group compared to control group. Allelic frequency analysis showed that individuals carrying the A allele have relatively decreased risk for breast cancer. The stratification analysis showed that IL-8 rs4073 genotypes were protective markers for those with younger (≤55) age. Conclusion: IL-8 rs4073 A allele is a novel predictor for breast cancer, especially TNBC.Breast cancer is the most prevalent and death-causing cancer among women worldwide (1). Although the survival rates of breast cancer patients have been improved with modern medical care, the breast cancer-related global death rate remains high (1). Among the several subtypes, triple negative breast cancer (TNBC) occupies 15%-20% of all invasive breast cancers and is characterized by a high metastasis and recurrence rate and poor survival (2, 3). Globally, TNBC is in lack of effective drugs. In Taiwan, breast cancer has the highest incidence among all cancers (4, 5). It is reported that high-caloric intake, high-fat diets, early menarche age, late menopause age, together with overweight/obesity, and exposure to pollutants are typical breast cancer risk factors in Taiwan (6). Several studies have investigated biomarkers and genetic variants for the early detection of breast cancer. For instance, carriers of BRCA1/BRCA2 mutations are at higher risk of breast cancer (7-10). However, BRCA1 and BRCA2 genetic variants can explain the etiology of a small percentage of breast cancer cases. Translational scientists are interested in identifying biomarkers for TNBC (11-13).Chronic inflammation can induce DNA damage and may lead to carcinogenesis (14-16). Interleukin-8 (IL-8, also named CXCL8), is related to inflammation, and plays a role in many cellular processes including intersection of cancer plasticity, angiogenesis, and immune suppression (17). 3799 *These Authors contributed equally to the study.

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Contribution of Interleukin-12A Genotypes to Breast Cancer Risk

Cited by 2 publications

References 38 publications

The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan

The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan

The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan

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