Contribution of Intramuscular Oxidative Metabolism to Total ATP Production during Forearm Isometric Exercise at Varying Intensities

Kimura, Naoto; Hamaoka, Toshiyuki; Kurosawa, Yuko; Katsumura, Toshihito

doi:10.1620/tjem.208.307

Cited by 11 publications

(15 citation statements)

References 24 publications

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“…First, as suggested by earlier studies (Morvan et al ., ; Morvan & Leroy‐Willig, ; Ababneh et al ., ; Yanagisawa et al ., ), it could be assumed that increased muscle temperature partly contributed to the ADC elevation during the exercise with 50% MVC. Exercising muscle enhances the metabolic activity to continuously resynthesize adenosine triphosphate during sustained muscle contraction (Jubrias et al ., ; Kimura et al ., ; Lanza et al ., ). Consequently, the movement of intramuscular water molecules might have been activated, accompanying exercise‐induced heat production.…”

Section: Discussionmentioning

confidence: 99%

“…These data were converted to 1‐min interval data and expressed as the changed volume with respect to the 1‐min pre‐exercise value. We used the total Hb/Mb value as an index of the intramuscular blood volume (Tachi et al ., ; Kimura et al ., ).…”

Section: Methodsmentioning

confidence: 97%

“…We also tried to investigate the water molecular movement within the exercised muscle in the acute recovery period after exercise. Moreover, using the same exercise protocol, we assessed the state of intramuscular blood volume before, during and after the exercise using near‐infrared spectroscopy (NIRS) (Tachi et al ., ; Kimura et al ., ), to better understand the effect of intramuscular microcirculation on the muscle ADC value.…”

Section: Introductionmentioning

confidence: 99%

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Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities

Yanagisawa

Kurihara

2015

Clin Physio Funct Imaging

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We aimed at evaluating the effect of isometric muscle contraction on intramuscular water movement at different exercise intensities. Seven men performed 1-min isometric ankle dorsiflexion (20% and 50% maximal voluntary contractions [MVCs]) with a non-magnetic custom-made dynamometer, inside a magnetic resonance (MR) device. Axial diffusion-weighted images were obtained before, during and at 1-20 min (1-min interval) after the exercise to calculate the apparent diffusion coefficient (ADC) of the tibialis anterior. Under the same exercise condition, the concentration change of total haemoglobin (Hb) and myoglobin (Mb) (total Hb/Mb) within the tibialis anterior was assessed by performing near-infrared spectroscopy before, during and after the exercise outside the MR device. The 20% MVC exercise significantly increased the ADC only at 1 min postexercise (P<0·01), whereas the ADC significantly increased during and at 2-20 min after the 50% MVC exercise (P<0·01). The 20% MVC exercise decreased the total Hb/Mb during exercise (P<0·01), but the value significantly increased at 1 min postexercise (P<0·01). The total Hb/Mb significantly decreased during the 50% MVC exercise, but significantly increased at 1-5 min postexercise (P<0·01). One-minute moderate-intensity isometric exercise activates intramuscular water movement during and after the exercise. This activation was found even after a low-intensity exercise, but the effect was small and did not last long. The effect of intramuscular hyperaemia on the postexercise ADC elevation may be limited to the very early period after low- to moderate-intensity exercises.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities

Yanagisawa

Kurihara

2015

Clin Physio Funct Imaging

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“…ATP synthesis requires transport of pyruvate, which is a product of the glycolytic pathway in the cytosol, to the mitochondria. Glycolysis also yields 2 molecules of ATP [17,18,19]. Therefore, mitochondria and glycolysis play important roles in cellular energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

Hochuekkito, a Japanese Herbal Medicine, Restores Metabolic Homeostasis between Mitochondrial and Glycolytic Pathways Impaired by Influenza A Virus Infection

Takanashi

Dan²,

Kanzaki³

et al. 2017

Pharmacology

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Background: Hochuekkito (HKT), a traditional Japanese herbal medicine (Kampo), has been used to treat symptoms of several diseases. In a recent clinical study, HKT was shown to be protective against the influenza virus infection. However, the underlying mechanism of the prophylactic effect is not clear. Mitochondrial and glycolytic pathways play important roles in cellular energy metabolism to maintain biological functions. These metabolic pathways are affected by the influenza virus infection. In this study, we examined the relationship between the preventive effects of HKT against the influenza virus infection and cellular energy metabolism in mitochondria and glycolysis using Madin-Darby canine kidney cells and influenza A/PR/8/34 (H1N1) virus (IAV). Methods: Mitochondrial and glycolytic metabolic pathways were evaluated on the basis of the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), respectively, using the XF24 Extracellular Analyzer. Results: The OCR/ECAR ratio in IAV-infected cells was lower than that in control cells. Cells that were treated with HKT before IAV infection showed a metabolic pattern similar to that in the control cells (increase in both OCR and ECAR). Conclusions: Our results suggest that HKT not only activates both mitochondrial and glycolytic energy metabolism in IAV-infected cells but also helps maintain metabolic homeostasis similar to that in noninfected cells.

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“…Existem vários marcadores de lesão muscular, como a lactato desidrogenase (LDH), a creatina fosfoquinase (CPK), aldolase (ALD), citrato sintetase (CS), aspartato aminotransferase (AST), e a alanina aminotransferase (ALT) (1).…”

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Influência da função tireoidiana nos níveis séricos de CPK

Lima

Nóbrega

Nóbrega³

et al. 2012

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Determinar a variação da CPK sérica em função do TSH e T4 livre (FT4) e avaliar a CPK sérica nos estados patológicos da tireoide (hipertireoidismo e hipotireoidismo), em relação ao eutireoidismo. Materiais e métodos: Analisaram-se, retrospectivamente, 6.230 exames laboratoriais de 2007 a 2011, com as dosagens de TSH e CPK. Destas, 3.369 com dosagens de FT4. Avaliou-se a correlação entre CPK com TSH e com os estados patológicos da tireoide. Resultados: A correlação entre TSH e CPK foi positiva (r = 0,065), enquanto entre CPK e FT4 foi inversamente proporcional (r = -0,091, p < 0,05). Do total, 586 (9,4%) medidas foram de hipertireoidismo com mediana (intervalo) do CPK de 98 U/L (27 a 1.113) e 556 (8,9%), hipotireói-deos com CPK de 114 U/L (25-4.182). Conclusão: Houve correlação positiva entre CPK sérica e TSH e negativa com FT4, sendo a CPK menor no grupo com hipertireoidismo e maior no grupo de hipotireoidismo. Arq Bras Endocrinol Metab. 2012;56(3):190-4 Descritores TSH; creatina fosfoquinase; T4 livre; hipertireoidismo; hipotireoidismo ABSTRACT Objective: To determine serum CPK variation based on TSH e free T4 (FT4), and to assess serum CPK in pathological states of the thyroid (hyperthyroidism and hypothyroidism), in relation to the euthyroidism. Materials and methods: We evaluated retrospectively 6,230 laboratory results of TSH and CPK from 2007 to 2011. From these, 3,369 had free T4 results. We evaluated the correlation between CPK and TSH and the pathological states of the thyroid. Results: The correlation between TSH and CPK was positive (r = 0.065), while that between CPK and FT4 was negative (r = -0.091, p < 0.05). From the total of results analyzed, 586 (9.4%) were measures of hyperthyroidism, with a median (range) of CPK of 98 U/L (27 to 1,113), and 556 (8.9%) were of hypothyroidism, with CPK of 114 U/L (25-4,182). Conclusion: A positive correlation was found between serum CPK and TSH, and a negative correlation between CPK and FT4. CPK was lower in the group with hyperthyroidism, and greater in that with hypothyroidism. Arq Bras Endocrinol Metab. 2012;56(3):190-4

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Contribution of Intramuscular Oxidative Metabolism to Total ATP Production during Forearm Isometric Exercise at Varying Intensities

Cited by 11 publications

References 24 publications

Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities

Intramuscular water movement during and after isometric muscle contraction: evaluation at different exercise intensities

Hochuekkito, a Japanese Herbal Medicine, Restores Metabolic Homeostasis between Mitochondrial and Glycolytic Pathways Impaired by Influenza A Virus Infection

Influência da função tireoidiana nos níveis séricos de CPK

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