Contribution of intrinsically photosensitive retinal ganglion cells in the photophobia of migraine patients

Tatsumoto, Muneto; Yamakawa, Masahiko; Okajima, Katsunori; Hirata, Koichi

doi:10.1016/j.jns.2015.08.577

Cited by 2 publications

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“…Among RGC subtypes, intrinsically photosensitive melanopsin (Opn4)-expressing RGCs (ipRGCs) transmit photic signals that influence innate functions, such as the synchronization of endogenous circadian rhythms to light-dark cycles (4)(5)(6). Studies using animal models, as well as data collected from human subjects, have further implicated ipRGC signaling in modulating metabolic functions, cognition, and affective behavior (7)(8)(9)(10). We have recently delineated an ipRGC brain circuit that drives the deleterious effects of irregular light on mood-related behaviors in mice (11).…”

Section: Introductionmentioning

confidence: 99%

Daily changes in light influence mood via inhibitory networks within the thalamic perihabenular nucleus

et al. 2022

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Exposure to irregular lighting schedules leads to deficits in affective behaviors. The retino-recipient perihabenular nucleus (PHb) of the dorsal thalamus has been shown to mediate these effects in mice. However, the mechanisms of how light information is processed within the PHb remains unknown. Here, we show that the PHb contains a distinct cluster of GABAergic neurons that receive direct retinal input. These neurons are part of a larger inhibitory network composed of the thalamic reticular nucleus and zona incerta, known to modulate thalamocortical communication. In addition, PHb GABA neurons locally modulate excitatory-relay neurons, which project to limbic centers. Chronic exposure to irregular light-dark cycles alters photo-responsiveness and synaptic output of PHb GABA neurons, disrupting daily oscillations of genes associated with inhibitory and excitatory PHb signaling. Consequently, selective and chronic PHb GABA manipulation results in mood alterations that mimic those caused by irregular light exposure. Together, light-mediated disruption of PHb inhibitory networks underlies mood deficits.

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