Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia

Pei, Jen Sheng; Chou, An‐Kuo; Hsu, Pei-Chen; Tsai, Chia Wen; Chang, Wen Shin; Wu, Meng; Wu, Ming; Hsia, Te Chun; Cheng, Shun Ping; Bau, Da Tian

doi:10.21873/anticanres.12126

Cited by 15 publications

(12 citation statements)

References 28 publications

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“…In addition, MMP-8 C-799T, Val436Ala, or Lys460Thr may play a minor role in determining personal susceptibility of childhood ALL (27). As for MMP-7, variant genotypes at A-181G but not C-153T were associated with a higher risk of childhood ALL, especially among boys and those aged less than 3.5 years at onset (29). In the future, the contribution of the genotypes of other MMPs, especially those whose proteins were identified to be differentially expressed among ALL patients and healthy controls, will be helpful to reveal the role of ECM dysregulation in ALL etiology.…”

Section: Discussionmentioning

confidence: 98%

“…The questionnaire well recorded the disease history, diet and sleeping habits of the child in addition to the disease history, diet, behavioral lifestyle and socioeconomic status of the parents. Then, 266 ageand gender-matched healthy participants were chosen as the control group following initial random sampling from the Health Examination Cohort established as we have previously published (27)(28)(29). Most of the volunteers underwent health examinations every 5 to 6 months with no gap longer than one year.…”

Section: Methodsmentioning

confidence: 99%

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Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia

et al. 2019

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Background/Aim: The association of matrix metalloproteinase-2 (MMP-2) genotypes with adult leukemia has been reported only once, but never for childhood leukemia. This study aimed to determine the role of MMP-2 promoter-1306 (rs243865) and-735 (rs2285053) genotypes in childhood leukemia risk. Materials and Methods: This case-control study included 266 patients and 266 age-and gender-matched healthy controls. The polymorphic sites of MMP-2 were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism. Results: The CC, CT and TT of rs243865 genotype were 75.2, 23.7 and 1.1% in the case group and 69.2, 28.9 and 1.9% in the control group, respectively. The CT and TT genotypes caused a 0.75-and 0.55-fold increase in the risk of childhood leukemia, respectively. There was no differential distribution of rs2285053 genotypes. Allelic frequency analysis showed that the T allele of MMP-2 promoter-1306 and-735 conferred lower susceptibility than the C allele. Conclusion: The MMP-2 promoter genotypes play a minor role in determining personal susceptibility to childhood leukemia among the Taiwanese.

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Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia

et al. 2019

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“…All investigated subjects voluntarily participating in this study, completed a questionnaire form with the help of their parents or guardians, and provided their peripheral blood samples less than 5 ml without any uncomfortable feelings. An equal number of age-matched healthy subjects without any cancer were recruited as the control group in accordance with the method for initial random sampling established by the Health Examination Cohort over the similar period of 2005 to 2010 as we previously published (3)(4)(5). Most healthy subjects underwent health examinations every 5 to 6 months.…”

Section: Methodsmentioning

confidence: 99%

“…The molecular etiology of ALL is not completely understood. Genome-wide and candidate-gene association studies show that genetic polymorphisms of some susceptibility genes are associated with the personal susceptibility of childhood ALL (1)(2)(3)(4)(5). In recent years, it has been reported that microRNAs (miRNAs) may play an important role in the regulation of hematopoiesis (6).…”

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confidence: 99%

Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan

Pei

Chang

Hsu

et al. 2020

Cancer Genomics Proteomics

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Background/Aim: Mounting evidence has shown that miRNAs play a critical role in the regulation of hematopoiesis of cell proliferation and apoptosis as well as in tumorigenesis. The miR146a rs2910164 polymorphism, which is closely responsive for its expression, has been reported to associate with the risk of several solid cancers. The study aimed at examining the association of the it with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. Materials and Methods: We recruited 266 patients with childhood ALL and 266 healthy controls, and rs2910164 genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The allele G was associated with decreased childhood ALL risk (OR=0.66, 95%CI=0.52-0.85, p=0.0011). Consistently, the GG genotype was associated with a decreased susceptibility (OR=0.40, 95%CI=0.23-0.67, p=0.0004). Patients with CG and GG genotypes were of earlier onset than those with CC genotype (p=0.0255 and p=0.0001). Conclusion: MiR146a rs2910164 G allele serves as a protective marker for childhood ALL in Taiwan.

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“…All investigated subjects voluntarily participated in this study, completed a questionnaire form with the help of their parents or guardians, and provided 5 ml of their peripheral blood samples without any uncomfortable feelings. An equal number of age-matched healthy subjects were recruited as the control group in accordance with the method for initial random sampling established by the Health Examination Cohort between 2005 to 2010 as previously described (29)(30)(31). Most of the healthy subjects underwent health examinations every 5 to 6 months.…”

Section: Methodsmentioning

confidence: 99%

HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

Hsu

Chen

Tzeng

et al. 2019

In Vivo

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Background/Aim: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. Results: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). Conclusion: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

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Contribution of Matrix Metalloproteinase-7 Genotypes to the Risk of Non-solid Tumor, Childhood Leukemia

Abstract: Our results indicate that the MMP7 A-181G genotype interacts with age and gender and may serve as an early and predictive biomarker for childhood ALL.

Cited by 15 publications

References 28 publications

Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia

Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia

Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan

HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

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