Contribution of microvascular dysfunction to chronic pain

Coderre, Terence J.

doi:10.3389/fpain.2023.1111559

Cited by 6 publications

(1 citation statement)

References 53 publications

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“…If we consider peripheralist perspectives, it is known that the peripheral nervous system can play an essential role in the production and maintenance of pain [33]. For example, there is a potential link between fibromyalgia and pathological changes in small nerve fibers, characterized by a reduction in the density of both myelinated and unmyelinated fibers [34], low-grade systemic inflammation which can affect nociception itself [35][36][37], changes in gut microbiota [38], and microvascular alterations, among other factors [39].…”

Section: Pain and Brain: A Mereological Fallacy We Should Abandonmentioning

confidence: 99%

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

Párraga,

Castellanos

2023

JCM

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Chronic pain has increasingly become a significant health challenge, not just as a symptomatic manifestation but also as a pathological condition with profound socioeconomic implications. Despite the expansion of medical interventions, the prevalence of chronic pain remains remarkably persistent, prompting a turn towards non-pharmacological treatments, such as therapeutic education, exercise, and cognitive-behavioral therapy. With the advent of cognitive neuroscience, pain is often presented as a primary output derived from the brain, aligning with Engel’s Biopsychosocial Model that views disease not solely from a biological perspective but also considering psychological and social factors. This paradigm shift brings forward potential misconceptions and over-simplifications. The current review delves into the intricacies of nociception and pain perception. It questions long-standing beliefs like the cerebral-centric view of pain, the forgotten role of the peripheral nervous system in pain chronification, misconceptions around central sensitization syndromes, the controversy about the existence of a dedicated pain neuromatrix, the consciousness of the pain experience, and the possible oversight of factors beyond the nervous system. In re-evaluating these aspects, the review emphasizes the critical need for understanding the complexity of pain, urging the scientific and clinical community to move beyond reductionist perspectives and consider the multifaceted nature of this phenomenon.

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Section: Pain and Brain: A Mereological Fallacy We Should Abandonmentioning

confidence: 99%

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

Párraga,

Castellanos

2023

JCM

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The association of the comorbidity status of metabolic syndrome and cognitive dysfunction with health-related quality of life

Lin,

Chang,

Wang

et al. 2024

Qual Life Res

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Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

Gkouvi,

Tsiogkas,

Bogdanos

et al. 2024

Curr Pain Headache Rep

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Purpose of Review Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the disease but may also reveal biomarkers for diagnosis or therapeutic targets. The present systematic review aims to synthesize the evidence regarding the proteome of adult patients with FMS using data from observational studies. Recent Findings An extensive literature search was conducted in MEDLINE/PubMed, CENTRAL, and clinicaltrials.gov from inception until November 2022. The study protocol was published in OSF. Two independent reviewers evaluated the studies and extracted data. The quality of studies was assessed using the modified Newcastle–Ottawa scale adjusted for proteomic research. Ten studies fulfilled the protocol criteria, identifying 3328 proteins, 145 of which were differentially expressed among patients with FMS against controls. The proteins were identified in plasma, serum, cerebrospinal fluid, and saliva samples. The control groups included healthy individuals and patients with pain (inflammatory and non-inflammatory). Summary The most important proteins identified involved transferrin, α-, β-, and γ-fibrinogen chains, profilin-1, transaldolase, PGAM1, apolipoprotein-C3, complement C4A and C1QC, immunoglobin parts, and acute phase reactants. Weak correlations were observed between proteins and pain sensation, or quality of life scales, apart from the association of transferrin and a2-macroglobulin with moderate-to-severe pain sensation. The quality of included studies was moderate-to-good. FMS appears to be related to protein dysregulation in the complement and coagulation cascades and the metabolism of iron. Several proteins may be dysregulated due to the excessive oxidative stress response.

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Contribution of microvascular dysfunction to chronic pain

Cited by 6 publications

References 53 publications

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

The association of the comorbidity status of metabolic syndrome and cognitive dysfunction with health-related quality of life

Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

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