Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

Amsterdam, Jan van; Talhout, Reinskje; Vleeming, W.; Opperhuizen, Antoon

doi:10.1016/j.lfs.2006.06.010

Cited by 53 publications

(32 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, similar decreases have been seen in type II alcoholism which also revert to normal when alcohol consumption ceases. A recent review concludes that the inhibition of MAO activity by constituents of tobacco and tobacco smoke enhances the addiction induced by tobacco smoking 19. A recent online publication suggested that harman and salsolinol, condensation products of acetaldehyde and biogenic amines, inhibit MAO.…”

Section: Tobacco Products and The Development Of Nicotine Dependencementioning

confidence: 99%

"Blowing in the wind": a review of teenage smoking

Lenney

Enderby

2008

Archives of Disease in Childhood

View full text Add to dashboard Cite

One quarter of all adults in the UK are regular smokers, the vast majority having started smoking in their teens. Teenage smoking, especially in females, continues to increase both as regards the numbers of cigarettes smoked and the numbers of teenagers who regularly smoke. The main factors influencing teenagers to smoke are peer pressure, family members who smoke and experimentation. Nicotine dependence can develop very quickly and in the UK little attention has been directed towards helping teenagers break the habit. In global terms the figures are frightening. Of the 1.25 billion smokers, 800 million live in developing countries. In the UK, government legislation, restrictions on advertising and educational programmes may improve the situation in the near future but there is still little recognition that smoking is responsible for 4 million deaths each year worldwide and insufficient attention has been paid to children and young families to try to prevent children and teenagers from smoking in the first place.

show abstract

Section: Tobacco Products and The Development Of Nicotine Dependencementioning

confidence: 99%

"Blowing in the wind": a review of teenage smoking

Lenney

Enderby

2008

Archives of Disease in Childhood

View full text Add to dashboard Cite

show abstract

“…Dysfunction of MAO is associated with a number of neurologic disorders, including Parkinson's, Alzheimer's and Huntington's diseases, major depression, and schizophrenia (for review see Lewis et al, 2007). Monoamine oxidases have also been shown to be inhibited by unknown compounds contained in tobacco smoke (Van Amsterdam et al, 2006). Several lines of evidence indicate that the MAO-A inhibition has a key role in the nicotine addiction (Guillem et al, 2006;Lewis et al, 2007;van Amsterdam et al, 2006;Villegier et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

In vivoQuantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [¹¹C]befloxatone and the Multi-Injection Approach

Bottlaender

Valette

Delforge

et al. 2009

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

[ 11 C]befloxatone is a high-affinity, reversible, and selective radioligand for the in vivo visualization of the monoamine oxidase A (MAO-A) binding sites using positron emission tomography (PET). The multi-injection approach was used to study in baboons the interactions between the MAO-A binding sites and [ 11 C]befloxatone. The model included four compartments and seven parameters. The arterial plasma concentration, corrected for metabolites, was used as input function. The experimental protocol-three injections of labeled and/or unlabeled befloxatone-allowed the evaluation of all the model parameters from a single PET experiment. In particular, the brain regional concentrations of the MAO-A binding sites (B 0 max ) and the apparent in vivo befloxatone affinity (K d ) were estimated in vivo for the first time. A high binding site density was found in almost all the brain structures (170±39 and 194±26 pmol/mL in the frontal cortex and striata, respectively, n = 5). The cerebellum presented the lowest binding site density (66 ± 13 pmol/mL). Apparent affinity was found to be similar in all structures (K d V R = 6.4±1.5 nmol/L). This study is the first PET-based estimation of the B max of an enzyme.

show abstract

“…While the inhibitory effect of cigarette smoking on platelet MAO velocity has been observed previously [16,21,23] , there are no data relating to platelet MAO affinity in smokers. It is not clear which tobacco constituents are responsible for the inhibition of MAO velocity, but a few candidates have been isolated from tobacco leaves/ cigarette smoke that act as competitive or mixed-type MAO inhibitors in vitro [35,36] . According to our results, it seems that in vivo cigarette smoking alters only V max , while substrate binding remains unaffected.…”

Section: Discussionmentioning

confidence: 99%

“…For example, an increase in MAO activity a week after withdrawal (in fact -a return to the normal values) reported by Coccini et al [40] , may be due to higher leukocyte contamination of alcoholic plasma samples (MAO activity in that study was related to the protein content; see discussion on this issue bellow), inadequate adjusting for smoking (not recorded in the control group), gender (disproportionate representation among groups), or something else. In a recent review of the subject [36] , the need to study the effect of alcohol withdrawal on MAO-B activity in type 2 alcoholics that were controlled for smoking was emphasized. Our study relates exactly to such a group of patients and demonstrated that withdrawal from alcohol did not influence platelet MAO V max in any direction.…”

Section: Discussionmentioning

confidence: 99%

Platelet Monoamine Oxidase Kinetics, Alcoholism Subtypes and Cigarette Smoking

et al. 2007

View full text Add to dashboard Cite

In trying to dissociate the effect of alcohol and tobacco use on platelet monoamine oxidase-B (MAO-B) activity, we compared the enzyme kinetics in controls (n = 66) and alcohol-dependent patients (n = 81), subdivided according to the severity of both, alcohol and tobacco use. Platelet MAO-B kinetics was measured spectrophotofluorimetrically in chronic alcohol intoxication and after 3 weeks abstinence. In alcoholic patients, an increased Michaelis-Menten constant (16%, p < 0.01) was shown, notwithstanding smoking status. Maximal velocity did not differ between patients and controls when adjusted for smoking. In cigarette smokers, a highly significant dose-dependent reduction of platelet MAO velocity (40%, p < 0.001) was demonstrated, with a similar degree of reduction in patients and controls. Tobacco use itself had no influence on MAO affinity. No differences were shown between subtype 1 and 2 alcoholics, or between the day of admission and the 21st day of abstinence. In conclusion, it seems that both, alcohol and tobacco consumption, may contribute to the lowering of overall platelet MAO-B activity. The effect of alcohol is small, due to interference with substrate binding, and not alteration of catalytic activity. In contrast, the effect of cigarette smoking is pronounced and relates to the dose-dependent reduction of platelet MAO velocity, with no influence on its affinity.

show abstract

Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

Cited by 53 publications

References 71 publications

"Blowing in the wind": a review of teenage smoking

"Blowing in the wind": a review of teenage smoking

In vivoQuantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [¹¹C]befloxatone and the Multi-Injection Approach

Platelet Monoamine Oxidase Kinetics, Alcoholism Subtypes and Cigarette Smoking

Contact Info

Product

Resources

About

Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

Cited by 53 publications

References 71 publications

"Blowing in the wind": a review of teenage smoking

"Blowing in the wind": a review of teenage smoking

In vivoQuantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [11C]befloxatone and the Multi-Injection Approach

Platelet Monoamine Oxidase Kinetics, Alcoholism Subtypes and Cigarette Smoking

Contact Info

Product

Resources

About

In vivoQuantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [¹¹C]befloxatone and the Multi-Injection Approach