Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric function

Kalafatakis, Konstantinos; Triantafyllou, Konstantinos

doi:10.1016/j.regpep.2011.04.005

Cited by 69 publications

(48 citation statements)

References 211 publications

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“…High amounts of NT are also present in endocrine-like cells localized in intestinal mucosa, whereby NT is released upon food intake, and contributes to regulation of gastrointestinal motility and secretion (Kalafatakis and Triantafyllou, 2011). Much less attention has been paid to consider the emerging role of NT in regulation of the cardiovascular system.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of neurotensin in regulation of the cardiovascular system

Osadchii

2015

European Journal of Pharmacology

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Section: Introductionmentioning

confidence: 99%

Emerging role of neurotensin in regulation of the cardiovascular system

Osadchii

2015

European Journal of Pharmacology

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“…NT and NMN are found in the brain and the gastrointestinal tract, where they contribute to a number of functions in mammals. In gastrointestinal tract, NT is involved in digestion, gut motility, intestinal neuroinflammation, and regeneration [8]. In the central nervous system, NT participates in hypothermia, antinociception, dopamine neurotransmission, and anterior pituitary hormone secretion [9].…”

Section: Introductionmentioning

confidence: 99%

“…In avian species, NT and an NT-related 6-amino-acid peptide corresponding to mammalian NMN (Lys, Asn, NT [8][9][10][11][12][13] ; LANT-6) have been purified from chicken intestine [13,14]. NT and LANT-6 also have an identical 4-amino acid sequence at the C-terminus and are encoded by the same precursor gene as in mammals [15].…”

Section: Introductionmentioning

confidence: 99%

“…

Abstract: Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT [8][9][10][11][12][13] ; are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated.

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confidence: 99%

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Effects of Neurotensin and LANT-6 on Food Intake in Chicks

Masuda¹

2015

AJLS

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Neurotensin (NT) and an NT-related peptide (Lys, Asn, NT [8][9][10][11][12][13] ; are produced in the chicken brain and intestine, and these peptides are encoded by the same precursor gene (NT/LANT-6 precursor). Although it has been reported that the central administration of NT suppresses food intake in mammals, the effect of NT and LANT-6 on feeding behavior in birds has not yet been investigated. In this paper, we analyzed the expression levels of NT/LANT-6 precursor and the NT receptor (NTR1) mRNAs in the hypothalamic infundibulum, an important region for regulating feeding behaviors. We also examined the effects of NT and LANT-6 administration on food intake in chicks. Real-time PCR analysis showed that NT/LANT-6 precursor and NTR1 mRNAs had moderately high expression in the hypothalamic infundibulum. Further, in the hypothalamic infundibulum, the mRNA level of NT/LANT-6 precursor showed a trend toward increasing during postnatal development and increased 2.9-fold after a 48 hour fast, although the NTR1 mRNA level was not changed in both analyses. Contrary to our expectations, central administration of NT or LANT-6 had no effect on food intake in chicks.

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“…Neurotensin binds to three different receptors: neurotensin receptor 1 and 2 (Ntsr1 and Ntsr2), which are G-protein-coupled receptors, and neurotensin receptor 3 (Ntsr3), which is non-G-protein-coupled and also known as Sortilin-1 (SORT1; refs. 4,5). Interestingly, neurotensin has trophic effects on both normal and neoplastic tissue, and neurotensin and Ntsr1 have been suggested to be prognostic tumor biomarkers (6,7).…”

Section: Introductionmentioning

confidence: 99%

Validation of Plasma Proneurotensin as a Novel Biomarker for the Prediction of Incident Breast Cancer

Melander¹,

Belting²,

Manjer³

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: High fasting plasma proneurotensin concentration was associated with the development of breast cancer in the Malm€ o Diet and Cancer Study (MDCS). Here, we aimed at replicating the initial finding in an independent second cohort.Methods: The Malm€ o Preventive Project (MPP) is a population study and comprised 18,240 subjects when examined in [2002][2003][2004][2005][2006]. Of women without history of breast cancer at examination, we included all who developed breast cancer during follow-up (n ¼ 130) until December 31, 2010, and a random sample of women without breast cancer until the end of follow-up (n ¼ 1,439) for baseline plasma proneurotensin assessment (mean age, 70.0 AE 4.4 years). Proneurotensin was measured in fasting plasma samples and was related to the risk of later breast cancer development using multivariate logistic regression.Results: Proneurotensin [odds ratio (OR) per standard deviation (SD) increment of LN-transformed proneurotensin] was significantly related to incident breast cancer [OR, 2.09; 95% confidence interval (CI), 1.79-2.44; P < 0.001; adjusted for age, body mass index (BMI), smoking, and hormone replacement therapy]. The effect estimate in the MPP was larger than in the discovery cohort (MDCS), with the main difference between the two cohorts being that women of the MPP study were on the average about 10 years older and follow-up time was shorter than that of the MDCS.Conclusion: As initially found in the MDCS, fasting plasma proneurotensin was significantly associated with the development of breast cancer in the MPP study as well.Impact: Measurement of plasma proneurotensin warrants further investigation as a blood-based marker for early breast cancer detection. Cancer Epidemiol Biomarkers Prev; 23(8); 1672-6. Ó2014 AACR.

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Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric function

Cited by 69 publications

References 211 publications

Emerging role of neurotensin in regulation of the cardiovascular system

Emerging role of neurotensin in regulation of the cardiovascular system

Effects of Neurotensin and LANT-6 on Food Intake in Chicks

Validation of Plasma Proneurotensin as a Novel Biomarker for the Prediction of Incident Breast Cancer

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