Contribution of research on ‘Epilepsy & Behavior’ to the refinement of functional brain atlas in four dimensions

Abstract

Intracranial stimulation mapping by Penfield et al. largely contributed to our current knowledge of the functional organization of motor, sensory, and language systems. The functional maps were generated and printed in two dimensions, based on the summary results of direct cortical stimulation of which locations varied across patients. Intracranial measurement of electrocorticographic changes elicited by a task can localize the regions involved in or participating to the given task. Augmentation of high-gamma activity at >80 Hz is considered to reflect in situ cortical activation at each moment. In the late 2000s, the spatial-temporal profiles of event-related high-gamma activity began to be published as a video material in journals. We have referred to our animation movie as ‘in-vivo animation of event-related high-gamma activity’, that demonstrates ‘when’ and ‘where’ cortical regions are activated in a self-explanatory fashion. Summation of event-related high-gamma measures derived from a large cohort of patients, as previously performed by Penfield et al, is expected to generate unique four-dimensional functional brain atlas covering the whole cerebral cortex.