2005
DOI: 10.1002/jps.20285
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Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes

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Cited by 101 publications
(78 citation statements)
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“…Pigment dispersion caused a significant IOP elevation at the 48-hour time interval, while RKI-1447 partially reversed this effect throughout the study. The TM regulates aqueous outflow by changing its cytoskeleton, stiffness, cell adhesion, migration, contraction, and phagocytosis 32,33 , and ROCK signaling plays a central role in these processes 7,34 .…”
Section: Discussionmentioning
confidence: 99%
“…Pigment dispersion caused a significant IOP elevation at the 48-hour time interval, while RKI-1447 partially reversed this effect throughout the study. The TM regulates aqueous outflow by changing its cytoskeleton, stiffness, cell adhesion, migration, contraction, and phagocytosis 32,33 , and ROCK signaling plays a central role in these processes 7,34 .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, we examined whether ROCK inhibitors, like many other IOP-reducing drugs, relax the ciliary arteries and may potentially serve as ocular vasodilators. We investigated the effects of two ROCK inhibitors, Y-27632 [22] and Y-39983 [23], on the tension of isolated rabbit ciliary arteries.…”
Section: Introductionmentioning
confidence: 99%
“…Nakajima and collaborators found both ROCK isoforms in CM and TM. Both in humans and in monkeys ROCK1 was expressed in TM more abundantly than in CM, and the ROCK inhibitor Y-39983 led to relaxation of monkey TM, with only a slight effect in relaxing CM [36].…”
Section: Discussionmentioning
confidence: 98%