Contribution of skeletal muscle to nonshivering thermogenesis in the dog

Tr, Davis

doi:10.1152/ajplegacy.1967.213.6.1423

Cited by 28 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the suggestion that skeletal muscle also plays a role in NST during cold adaptation (4,5,7,28,29), it remains unclear to what extent muscle-based NST is activated during prolonged cold adaptation. Also, the presence of functionally active BAT may influence the contribution from muscle.…”

Section: Discussionmentioning

confidence: 99%

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function

Bal

Maurya

Singh

et al. 2016

Journal of Biological Chemistry

102

View full text Add to dashboard Cite

Skeletal muscle has been suggested as a site of nonshivering thermogenesis (NST) besides brown adipose tissue (BAT). Studies in birds, which do not contain BAT, have demonstrated the importance of skeletal muscle-based NST. However, musclebased NST in mammals remains poorly characterized. We recently reported that sarco/endoplasmic reticulum Ca 2؉ cycling and that its regulation by SLN can be the basis for muscle NST. Because of the dominant role of BAT-mediated thermogenesis in rodents, the role of muscle-based NST is less obvious. In this study, we investigated whether muscle will become an important site of NST when BAT function is conditionally minimized in mice. We surgically removed interscapular BAT (iBAT, which constitutes ϳ70% of total BAT) and exposed the mice to prolonged cold (4°C) for 9 days. The iBAT-ablated mice were able to maintain optimal body temperature (ϳ35-37°C) during the entire period of cold exposure. After 4 days in the cold, both sham controls and iBAT-ablated mice stopped shivering and resumed routine physical activity, indicating that they are cold-adapted. The iBAT-ablated mice showed higher oxygen consumption and decreased body weight and fat mass, suggesting an increased energy cost of cold adaptation. The skeletal muscles in these mice underwent extensive remodeling of both the sarcoplasmic reticulum and mitochondria, including alteration in the expression of key components of Ca 2؉ handling and mitochondrial metabolism. These changes, along with increased sarcolipin expression, provide evidence for the recruitment of NST in skeletal muscle. These studies collectively suggest that skeletal muscle becomes the major site of NST when BAT activity is minimized.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function

Bal

Maurya

Singh

et al. 2016

Journal of Biological Chemistry

102

View full text Add to dashboard Cite

show abstract

“…Comparisons of large and small mammals and birds yield striking differences in apparent means of thermogenesis (Table 1). Studies in large mammals, including adult rabbits, dogs, and marsupials, where BAT is less prevalent, underscore the importance of skeletal muscle-based NST in facultative thermogenesis (Davis, 1967; Rose et al , 1999; Arruda et al , 2008); whereas, studies on small mammals, namely rodents, focus on BAT as the principal contributor to NST. These species-specific recruitment strategies are discussed in more detail below.…”

Section: Non-shivering Thermogenic Origins In Skeletal Musclementioning

confidence: 99%

“…In addition, there are several endotherms such as birds, marsupials, and wild boars that can maintain constant T c and thrive in cold climates without BAT. Several studies have suggested that skeletal muscle could be an important site of NST (Davis, 1967; Barre et al , 1989; Bourhim et al , 1990; Duchamp et al , 1991; Duchamp & Barre, 1993; Eldershaw et al , 1997); however, the mechanistic details of muscle-based NST are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

The role of skeletal‐muscle‐based thermogenic mechanisms in vertebrate endothermy

2014

View full text Add to dashboard Cite

Thermogenesis is one of the most important homeostatic mechanisms that evolved during vertebrate evolution. Despite its importance for the survival of the organism, the mechanistic details behind various thermogenic processes remain incompletely understood. Although heat production from muscle has long been recognized as a thermogenic mechanism, whether muscle can produce heat independently of contraction remains controversial. Studies in birds and mammals suggest that skeletal muscle can be an important site of non-shivering thermogenesis (NST) and can be recruited during cold adaptation, although unequivocal evidence is lacking. Much research on thermogenesis during the last two decades has been focused on brown adipose tissue (BAT). These studies clearly implicate BAT as an important site of NST in mammals, in particular in newborns and rodents. However, BAT is either absent, as in birds and pigs, or is only a minor component, as in adult large mammals including humans, bringing into question the BAT-centric view of thermogenesis. This review focuses on the evolution and emergence of various thermogenic mechanisms in vertebrates from fish to man. A careful analysis of the existing data reveals that muscle was the earliest facultative thermogenic organ to emerge in vertebrates, long before the appearance of BAT in eutherian mammals. Additionally, these studies suggest that muscle-based thermogenesis is the dominant mechanism of heat production in many species including birds, marsupials, and certain mammals where BAT-mediated thermogenesis is absent or limited. We discuss the relevance of our recent findings showing that uncoupling of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by sarcolipin (SLN), resulting in futile cycling and increased heat production, could be the basis for NST in skeletal muscle. The overall goal of this review is to highlight the role of skeletal muscle as a thermogenic organ and provide a balanced view of thermogenesis in vertebrates.

show abstract

“…However in adult stages of large mammals it is either absent or a minor component (as found in humans) and therefore large mammals have to rely on muscle for their adaptive thermogenesis. Several studies have shown that skeletal muscle also plays an important role in nonshivering thermogenesis [39–41] and especially, the sarcoplasmic reticulum (SR) Ca 2+ -transport might be an important component in nonshivering thermogenesis [42]. The importance of SR Ca 2+ -ATPase (SERCA) in heat generation was initially demonstrated in a group of endothermic open-ocean billfishes called blue marlin (of the genus Makaira ) [43, 44].…”

Section: Sr Ca2+ Cycling Plays a Role In Muscle Thermogenesismentioning

confidence: 99%

Sarcolipin is a novel regulator of muscle metabolism and obesity

Maurya

Periasamy

2015

Pharmacological Research

View full text Add to dashboard Cite

Obesity is increasing at an alarming rate, both in adults and adolescents, across the globe due to increased consumption of caloric rich diet. Obesity and its associated complications appear to be major contributing factors not only to diabetes/heart disease but also to cancer, and neurological diseases causing a huge burden on the health care system. To date, there are no effective treatments to reduce weight gain, other than caloric restriction and exercise which are often difficult to enforce. There are very few drugs available for treating obesity and those that are available only reduce obesity by ~10%. Identifying mechanisms to increase energy expenditure, on top of the increase elicited by exercise, would be more beneficial to control weight gain. The purpose of this review is to highlight the role of sarcolipin (SLN), a regulator of SERCA pump, in muscle thermogenesis and metabolism. We will further discuss if enhancing SLN activity could be an effective mechanism to increase energy expenditure and control weight gain. We will also discuss the merits of adaptive thermogenesis in muscle and brown fat as potential mechanisms to increase energy expenditure during caloric overload. That said, there is still a great need for further research into the mechanism of diet induced thermogenesis and its relevance to overall metabolism and obesity.

show abstract

Contribution of skeletal muscle to nonshivering thermogenesis in the dog

Cited by 28 publications

References 0 publications

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function

The role of skeletal‐muscle‐based thermogenic mechanisms in vertebrate endothermy

Sarcolipin is a novel regulator of muscle metabolism and obesity

Contact Info

Product

Resources

About