2008
DOI: 10.1128/jcm.02091-07
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Contribution of the (1→3)-β- d -Glucan Assay for Diagnosis of Invasive Fungal Infections

Abstract: Diagnosis of invasive fungal infection (IFI) remains, and in all who had P. jiroveci pneumonias (100%), and the false-positive rate varied depending on the controls used. It allowed a higher rate of detection among IPA patients compared to the galactomannan enzyme-linked immunosorbent assay (ELISA) (48 versus 39 patients, respectively) and among candidemia patients compared to the mannan ELISA (20 versus 11 patients, respectively). This assay therefore appears to be useful in the diagnosis of IFI, particularly… Show more

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Cited by 164 publications
(134 citation statements)
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“…Although LDH and pneumothorax are described as prognostic factors in previous reports (17) (18). The utility of serum β-Dglucan in the adjunct diagnosis of PCP has been proved in several studies (3)(4)(5)(6). However, these studies have been conducted on a small number of patients.…”
Section: In the Present Study We Evaluated The Laboratory And Bal Fimentioning
confidence: 88%
“…Although LDH and pneumothorax are described as prognostic factors in previous reports (17) (18). The utility of serum β-Dglucan in the adjunct diagnosis of PCP has been proved in several studies (3)(4)(5)(6). However, these studies have been conducted on a small number of patients.…”
Section: In the Present Study We Evaluated The Laboratory And Bal Fimentioning
confidence: 88%
“…As the design of these studies was very variable, only 10 (4 case-control and 6 cohort studies) [17][18][19][20][21][22][23][24][25][26] were considered appropriate for analysis on the basis of the following parameters: type of population (hematological patients), sample size (X20 IFD cases and X50 non-IFD controls) and reference standard of IFD (definition according to the EORTC/MSG criteria). 10 Whereas sensitivity, specificity, positive and negative predictive values derived from these analyses in hematological patients were variable (Table 3), no major differences were observed among the different assays.…”
Section: B-glucan (Bg)mentioning
confidence: 99%
“…Different studies have established its diagnostic value in invasive candidiasis and invasive aspergillosis (9,10). However, currently numerous non-Candida and non-Aspergillus fungi are important causes of IFD in the immunocompromised host, and in this setting, clinical and mycological experience with the use of BG as a tool for diagnosis is scarce (7)(8)(9)(10)(11). The aim of this report was to assess the usefulness of BG detection (Fungitell; Associates of Cape Cod, Falmouth, MA) as a diagnostic adjunct in proven IFD in a mixed population with uncommon fungal infections due to emerging dematiaceous and hyaline septate molds (14) or with an unusual clinical presentation.…”
mentioning
confidence: 99%