Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance

Sasaki, Ryoki; Watanabe, Hiraku; Miyaguchi, Shota; Otsuru, Naofumi; Ohno, Ken; Sakurai, Noriko; Kodama, Naoki; Onishi, Hideaki

doi:10.1016/j.bbr.2021.113433

Cited by 4 publications

(5 citation statements)

References 42 publications

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“…Studies on animals have shown that exercising during pregnancy can have a long-term effect on the offspring's BDNF levels [73] and there are initial ndings suggesting similar outcomes in humans as well [74]. BDNF is thought to play a role in enhancing motor skills [75] through various interconnected mechanisms. It supports the growth and upkeep of neurons in the motor system, aids in the transformation of progenitor cells into mature neurons, and impacts synaptic plasticity in the motor cortex and circuits [76].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Sabaghi,

Yousofvand

2024

Preprint

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Objective Seizures during pregnancy have been linked to adverse outcomes for newborns and motor coordination (MC) defects in offspring. Physical activity has shown promise in reducing seizure severity and promoting positive outcomes for newborns. In this study, we investigated the impact of aerobic exercise during pregnancy on seizure activity in pregnant mice treated with pentylenetetrazole (PTZ) and the MC of preadolescence male mice.Methods Adult female ICR mice were divided into two groups and administered PTZ or saline for 30 days before mating. PTZ treatment continued throughout pregnancy for the experimental group, while the control group received saline. Active pregnant mice engaged in aerobic treadmill exercises from the first to the 20th day of pregnancy. MC in preadolescence male offspring was assessed using the rotarod test.Results Prenatal exposure to maternal seizures induced by PTZ resulted in MC deficiencies in preadolescence male offspring (P < 0.05). Aerobic exercise during pregnancy demonstrated beneficial effects on convulsive activity (P < 0.05) and was able to counteract the MC deficits caused by maternal seizures during pregnancy.Conclusion These findings suggest aerobic exercise during pregnancy may serve as a supplementary therapeutic approach to reduce convulsive activity and mitigate MC impairments in preadolescence male offspring.

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Section: Discussionmentioning

confidence: 99%

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Sabaghi,

Yousofvand

2024

Preprint

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“…BDNF may be responsible for improved motor learning [43] and possibly also improved motor performance [44] due to multiple mechanisms that cannot be isolated. BDNF supports the growth and maintenance of neurons in the motor system and promotes the differentiation of progenitor cells into mature neurons.…”

Section: Discussionmentioning

confidence: 99%

Maternal Exercise during Pregnancy Impacts Motor Performance in 9-Year-Old Children: A Pilot Study

Ferrari,

Schmidt,

Bae-Gartz

et al. 2023

Children

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The benefits of maternal physical activity during pregnancy are well documented, but long-term effects on the child have been less studied. Therefore, we conducted a pilot follow-up study of a lifestyle intervention during pregnancy that aimed to investigate whether exercise (endurance and strength training) during pregnancy affects motor performance and body composition of children up to 9 years of age, as well as possible influencing factors like brain-derived neurotrophic factor (BDNF) and lifestyle. Eleven mother−child pairs from the intervention and eight mother−child pairs from the control group were included. From birth up to 9 years of age, no differences in body mass index (BMI) or body mass index standard deviation scores (BMI-SDS) were found between the groups. Lifestyle intervention was one of the influencing factors for children’s cardiorespiratory endurance capacity and coordination. Moreover, maternal BDNF in the last trimester was significantly associated with running performance, which may be due to better neuronal development. This is the first study evaluating the effects of a lifestyle intervention during pregnancy on the motor performance 9 years after birth. Children’s participation in exercise programs over the past 9 years was not continuously recorded and therefore not included in the analysis. Even a cautious interpretation of these results indicates that a healthy lifestyle during pregnancy is essential in promoting child health. Larger studies and randomized control trials are necessary to confirm our results, especially those pertaining to the role of BDNF.

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“…Based on the physics of mind theory, it is accepted that the bodily activity underlying human behaviour is accessible to perception and can determine human feelings (Perlovsky & Schoeller, 2019), depending on the capacity of individuals to perform (Sasaki et al, 2021) and in their regulation of their emotion state (Greipl et al, 2021). Supporting those studies, this study found that there was no difference in gameplay anxiety when comparing the two types of game playing, thus indicating that H1‐1 was not supported.…”

Section: Discussionmentioning

confidence: 99%

“…However, game devices might facilitate positive or negative emotions (Ninaus et al, 2019). It is widely known that a difference in motor movement exists in the capacity of individuals to perform (Sasaki et al, 2021) and that it regulates their emotional state (Greipl et al, 2021). In this study, when participants played games with two different motor movements, the result showed that H1‐2 was supported and indicated that their gameplay interest in Shaking‐On was higher than that in Kahoot!.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it was possible that the digital games adopted in the course would affect students' learning, and the different movements might also influence their learning outcome. For example, a previous finding suggested that greater movement volume brings higher neurotransmission, thereby resulting in better learning performance (Sasaki et al, 2021). Accordingly, games with different operation movements may also influence learning performance.…”

Section: Discussionmentioning

confidence: 99%

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Comparing the Taiwanese learning effects of Shaking‐On and Kahoot!

Hong

Tai

Luo

et al. 2022

Computer Assisted Learning

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Background: Many gamification applications (apps) have been designed to motivate students to learn particular content. Based on the brain activation approach, the present study adapted an app, named Shaking-On, which requires students to shake their mobile devices to send their answers to multiple-choice questions to the teacher. Students then learn from their performance.Objectives: To understand how this approach can stimulate participants' emotions when achieving their learning goals, the present study compared Shaking-On to Kahoot! by checking participants' gameplay anxiety, learning interest, perceived learning value, and learning achievement while learning the Taiwanese language.Methods: The students were divided into two groups to play with one of the two apps, Shaking-On or Kahoot!, as part of a quasi-experimental study in which they used the assigned app six times in 6 weeks. Moreover, a questionnaire was distributed to participants and 151 useful responses from the Shaking-On group, and 148 from the Kahoot! group were returned.Results and Conclusions: After statistical analysis, the results of this study revealed that besides no difference in gameplay anxiety when comparing the two groups of students, there were significant differences in game interest, flow experience, perceived learning value, and learning achievement, further indicating that Shaking-On with hands-on shaking outperformed Kahoot!.

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Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance

Cited by 4 publications

References 42 publications

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Beneficial Impact of Aerobic Exercise During Pregnancy on Motor Coordination Deficits Induced by PTZ in Preadolescent Male Mice

Maternal Exercise during Pregnancy Impacts Motor Performance in 9-Year-Old Children: A Pilot Study

Comparing the Taiwanese learning effects of Shaking‐On and Kahoot!

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