Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery

Long, Dustin R.; Bryson-Cahn, Chloe; Waalkes, Adam; Holmes, Elizabeth A.; Penewit, Kelsi; Tavolaro, Celeste; Bellabarba, Carlo; Zhang, Fangyi; Chan, Jeannie D.; Fang, Ferric C.; Lynch, John B.; Salipante, Stephen J.

doi:10.1126/scitranslmed.adk8222

Cited by 11 publications

(1 citation statement)

References 65 publications

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“…In broilers, the gut microbiota are well characterized within the ceca and have been directly linked to animal health and performance [42]. Recently, it has been discovered in humans that surgical site infections (SSI) are closely connected to a patient's immediate preoperative microbiome [43]. Despite the inherent differences across species, there are grounds to consider the characterization of broiler gut microbial communities and their impacts on BCO lameness etiology and pathogenesis-particularly concerning the concept of a "leaky gut" and its association with infection of leg bone microfractures in a similar fashion to SSIs.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Impact of Spraying an Enterococcus faecium-Based Probiotic on Day-Old Broiler Chicks at Hatch on the Incidence of Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Staphylococcus Challenge Model

Do,

Anthney,

Alharbi

et al. 2024

Animals

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Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a bone disease characterized by the translocation of bacteria from the gastrointestinal tract, which colonize microfractures in broiler leg bones caused by rapid animal growth rate and weight gain, resulting in lameness. As such, BCO lameness represents a significant challenge for the poultry industry. This study aims to evaluate the effect of spraying broiler chicks on d0 at hatch with an Enterococcus faecium probiotic on the incidence of BCO-induced lameness, utilizing a Staphylococcus aureus challenge model. There were four treatments: (1) negative control (no probiotic + no challenge, NC); (2) positive control (no probiotic + challenge, PC); (3) low dosage (4.0 × 108 CFU/chick + challenge, LOW); and (4) high dosage (2.0 × 109 CFU/chick + challenge, HIGH). On d5, groups two through four were challenged with Staphylococcus aureus through the drinking water at a concentration of 1.0 × 105 CFU/mL. Cumulative lameness incidence was determined through daily evaluations and necropsies conducted on lame birds starting from d22. Data were subjected to a binomial general regression analysis (significant p < 0.05). On d56, the PC group exhibited the highest cumulative lameness incidence (58.0%; p < 0.05), followed by LOW (36.0%), HIGH (28.7%), and NC groups (25.3%), respectively. These results suggest early probiotic application at day-of-hatch successfully reduced the incidence of lameness in challenged birds, thus contributing to understanding of efficient and sustainable broiler production.

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Section: Discussionmentioning

confidence: 99%

Assessing the Impact of Spraying an Enterococcus faecium-Based Probiotic on Day-Old Broiler Chicks at Hatch on the Incidence of Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Staphylococcus Challenge Model

Do,

Anthney,

Alharbi

et al. 2024

Animals

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Misapplication of Biologic Mesh in Clean-Site Elective Ventral Hernia Repair

Alverdy

2024

JAMA Surg

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Despite the aphorism that synthetic material should not be placed in a contaminated surgical field, the experience of trauma surgeons operating on a dirty wound in which an arterial graft must be placed to save a limb, that of an orthopedic surgeon replacing an infected weight-bearing prosthesis, as well as that a general surgeon encountering a large hernia in a contaminated site, seem to controvert this assertion. In response, "biosynthetic materials" have emerged as more "biologic." Yet the overall paradigm may have changed given the perceived safety of prolonged antibiotics, use of high-technology imaging, increased wound surveillance, and ability to safely operate multiple times on a patient. Have surgeons changed their practice to accommodate growing knowledge in the field? After all, we now understand that despite the most compelling evidence, it takes a physician more than 15 years to change practice when faced with new knowledge. 1 Enter the observational study by Mullens et al 2 demonstrating that while urgent/emergent repair and wound contamination are clearly associated with an increased odds of biologic or biosynthetic mesh use, nearly 90% of biologic and biosynthetic mesh use was applied in elective repairs with clean wound classifications among nearly 11 000 patients surveyed. These sobering observations should make us take pause

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Spine surgical site infection outcome with preoperative application of a presaturated 10% povidone-iodine nasal decolonization product in a 32-bed surgical hospital

Grant,

Crews-Stowe

2024

American Journal of Infection Control

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Contribution of the patient microbiome to surgical site infection and antibiotic prophylaxis failure in spine surgery

Cited by 11 publications

References 65 publications

Assessing the Impact of Spraying an Enterococcus faecium-Based Probiotic on Day-Old Broiler Chicks at Hatch on the Incidence of Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Staphylococcus Challenge Model

Assessing the Impact of Spraying an Enterococcus faecium-Based Probiotic on Day-Old Broiler Chicks at Hatch on the Incidence of Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Staphylococcus Challenge Model

Misapplication of Biologic Mesh in Clean-Site Elective Ventral Hernia Repair

Spine surgical site infection outcome with preoperative application of a presaturated 10% povidone-iodine nasal decolonization product in a 32-bed surgical hospital

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