The results of a systems study confirming on a new level the need to develop fast reactors with a closed nuclear fuel cycle and the best transition times to a closed nuclear fuel cycle are presented. The results obtained show that nuclear fuel cycle closure is a necessary step for developing large-scale nuclear power in the country. Nuclear fuel cycle closure using fast reactors with inherent safety is justified economically even now.Nuclear fuel cycle closure has been discussed for many years. The focus on fast reactors with a nuclear fuel cycle was formulated in the strategy for development of the industry during the first half of the 21st century [1]. The present article reports the results of research performed at the Research and Development Institute of Power Engineering (NIKIET) which confirm on a new level the need and urgency for transitioning to a closed nuclear fuel cycle (NFC) [2][3][4].This research was performed using several dynamic systems models describing the nuclear power system of the country as a whole, including all its principal components, i.e., aggregated models of real objects of the same type, such as nuclear power plants with definite types of reactors, plants producing fuel and reprocessing irradiated fuel, and uranium enrichment plants. Possible directions for development were evaluated, comparing on the basis of selected criteria scenarios accepted for examination and reflecting different initial prerequisites and conditions: 1) the need for large-sale nuclear power, capable of considerably improving the fuel balance of the fuel-energy complex as a whole, is postulated;2) scenarios with rapid growth of nuclear power in the 21st century are studied; and 3) the following fundamental conditions make the development of nuclear power possible: acceptable with respect to safety (prevention of accidents entailing evacuation of the public) and ecology (the plan includes handling of nuclear materials in a closed NFC), technological support for nonproliferation of fissile materials, economic attractiveness (competitiveness), and energy security with respect to resource availability. NFC Closure Principles. For development on a large scale the safety of nuclear power must be brought up to a new level, removing all restrictions on development. This key provision can be met if fast reactors with inherent safety, which are capable of preventing serious accidents, are adopted as the basis for power generation. Fast reactors will make it possible to continually displace resource-dependent thermal reactors from the principal sector of generating capacities and to eliminate the mass production of fuel for them, guaranteeing the country's energy security with regards to resource supplies. Lowering NFC costs and realizing the potential for reducing the cost of safe fast reactors will make nuclear power economically attractive.In contrast to the well-known concept of two-component nuclear power with expensive fast breeder reactors and a forcibly maintained thermal-reactor fraction, an important conceptu...