Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil

Loureiro, Paula; Almeida‐Neto, Cesar de; Proietti, Anna Bárbara Carneiro; Capuani, Ligia; Gonçalez, Thelma T.; Oliveira, Cláudia Di Lorenzo; Leão, Silvana Carneiro; Lopes, Maria Inês; Sampaio, Divaldo; Patavino, Giuseppina Maria; Ferreira, João Eduardo; Blatyta, Paula Fraiman; Lopes, Maria Esther; Mendrone‐Júnior, Alfredo; Salles, Nanci Alves; King, Melissa R.; Murphy, Edward L.; Busch, Michael P.; Custer, Brian; Sabino, Éster Cerdeira

doi:10.5581/1516-8484.20140033

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…This report used data collected between 2013 and 2016 by the National Heart, Lung, and Blood Institute (NHLBI) REDS‐III China International program (2011‐2019) to provide an updated estimation of HCV prevalence and incidence and to identify factors that are associated with HCV infection among blood donors in China.…”

mentioning

confidence: 99%

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Lv²,

Zhang³

et al. 2019

Transfusion

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were screened in parallel by two different enzyme-linked immunosorbent assays for anti-HIV 1/2, hepatitis B surface antigen, anti-HCV, and syphilis. Screeningreactive samples were further confirmed by western blot. Confirmatory positive rates among first-time and repeat donors were used to estimate the prevalence and incidence rates. Multivariable logistic regression modeling was used to examine factors associated with HCV infection. RESULTS:A total of 1,276,544 donations were collected from five Chinese blood centers, of which an estimated 1203 were confirmed HCV positive. The overall HCV prevalence among first-time donors was 166.56 per 100,000 donors (95% confidence interval, 156.04-177.08). The HCV incidence rate was estimated to be 15.21 (95% confidence interval, 11.83-19.56) per 100,000 person-years among repeat donors. Multivariable logistic regression results showed that increased age, lower educational levels, ethnicity, and occupation were all important factors associated with HCV confirmatory status among first-time donors (p < 0.01). CONCLUSIONS: HCV infection is still an importantconcern for transfusion safety in China. Our findings indicate that continued strong efforts are needed to monitor and control the risk of transfusion-transmitted HCV infection in China. Moreover, to reduce unnecessary donor loss, HCV donor screening procedures should be improved by incorporating confirmatory testing into routine blood center operations. From the

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confidence: 99%

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Lv²,

Zhang³

et al. 2019

Transfusion

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“…REDS II is a multicentric research program funded and financed by the National Institute of Health (NIH) of the United States of America, which included Brazil as an international component in 2006. The main objectives of this program were to assess transfusion safety and the adequacy of blood supply in Brazil [ 15 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Comparison of Two Methods of Capillary Sampling in Blood Pre-Donation Anemia Screening in Brazil

et al. 2023

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Background: The laboratory tests most used by blood banks to diagnose anemia are the hemoglobin (Hb) and microhematocrit (Hct) tests, measured from capillary samples. Objective: To analyze the two capillary screening methods for pre-donation anemia by comparing their agreement in diagnosing anemia. Method: A cross-sectional study in a population of 15,521 blood donation candidates for whom information was available on Hb and Hct, performed from capillary blood samples. Hb was determined using the HemoCue® test and Hct by the centrifugation method. The Kappa coefficient was calculated to assess the agreement between the methods. Pearson’s correlation tests and gender-adjusted linear regression were used to assess the change in the response variable (Hb) as a function of the explanatory variable (Hct). Results: The majority of the study population were men (70.4%), aged between 18 and 44 years (72.1%), who declared themselves white or mixed skin color (85.6%), and had undergone at least 11 years of complete education (72.4%). The Kappa coefficient found was 92.7 and 99.2 for women and men, respectively. Pearson’s correlation showed a correlation coefficient of 0.98 and the linear regression graph showed an adequate relationship between the tests with R2 = 0.97. Conclusions: Comparing the Hb and Hct capillary tests, it was found that Hct can be safely used to screen for anemia in pre-blood donation.

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“…In 2011, the name was changed to Recipient Epidemiology and Donor Evaluation Study (REDS‐III). According to a recent publication from the REDS investigators, more than 60% of blood donors (apheresis and not) are under the age of 35, with two thirds being male . While it is common practice in Brazil to request that family and friends donate for their relatives who require transfusions, more than 60% of donors are motivated to donate spontaneously, on average 1.5 to 1.6 times a year.…”

Section: Apheresis Activity In Brazil In 2013mentioning

confidence: 99%

Apheresis in developing countries around the World

Eichbaum

Smid

Crookes³

et al. 2014

J of Clinical Apheresis

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At the combined American Society for Apheresis (ASFA) Annual Meeting/World Apheresis Association (WAA) Congress in San Francisco, California, in April of 2014, the opening session highlighted the status of apheresis outside of the United States. The organizers invited physicians active in apheresis in countries not usually represented at such international gatherings to give them a forum to share their experiences, challenges, and expectations in their respective countries with regard to both donor and therapeutic apheresis. Apheresis technology is expensive as well as technically and medically demanding, and low and median income countries have different experiences to share with the rest of the world. Apheresis procedures also require resources taken for granted in the developed world, such as reliable electrical power, that can be unpredictable in parts of the developing world. On the other hand, it was obvious that there are significant disparities in access to apheresis within the same country (such as in Brazil), as well as between neighboring nations in Africa and South America. A common trend in the presentations from Brazil, Indonesia, Malaysia, Nigeria, and South Africa, was the need for more and better physicians and practitioners' training in the indications of the various apheresis modalities and patient oversight during the procedures. As ASFA and WAA continue to work together, and globalization allows for increased knowledge-sharing, improved access to apheresis procedures performed by qualified personnel with safety and high-quality standards will be increasingly available.

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Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil

Cited by 5 publications

References 24 publications

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Comparison of Two Methods of Capillary Sampling in Blood Pre-Donation Anemia Screening in Brazil

Apheresis in developing countries around the World

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