Contribution of the trabecular component to mechanical strength and bone mineral content of the femoral neck. An experimental study on cadaver bones

Werner, C. R.; Iversen, Bjørn Franc; Therkildsen, M. H.

doi:10.3109/00365518809085757

Cited by 31 publications

(15 citation statements)

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“…Cancellous bone plays a signi®cant role in proximal femur integrity [32,33]. The preferred method to determine proximal femoral strength is a measurement of bone mineral density, which accounts for up to 90% of its strength [34,35].…”

Section: Discussionmentioning

confidence: 99%

Age-Related Cancellous Bone Loss in the Proximal Femur of Caucasian Females

Lundeen¹,

Vajda²,

Bloebaum³

2000

Osteoporosis International

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The purpose of this investigation was to directly define the age-related intrafemoral variations in cancellous bone density, bone mineralization and rate of bone loss in a cadaveric population of Caucasian female femoral necks and trochanters. Forty-three Caucasian female femora were obtained and divided into premenopausal, postmenopausal and elderly age groups. The neck and trochanter were removed, and cores of cancellous bone were taken from the superior, middle and inferior regions; volume fraction and ash fraction were determined for each core. The cancellous bone volume fraction of the neck was significantly greater than that of the trochanter, as was that of the inferior region of the neck compared with the superior and middle regions at all age groups (p<0.05). The mean neck/trochanter and neck inferior/superior volume fraction ratios did not change with age; however, the variance increased with age (p<0.001). This increasing variability with age suggests that there may be a subpopulation of individuals within the elderly Caucasian population with a significantly different intrafemoral bone density distribution than was present prior to menopause. This study identified no mineralization changes with age in the cancellous bone of the proximal femur (p>0.05). The influence of increased neck/trochanter and neck inferior/superior ratios on femoral neck integrity and fracture prediction is of interest and requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Age-Related Cancellous Bone Loss in the Proximal Femur of Caucasian Females

Lundeen¹,

Vajda²,

Bloebaum³

2000

Osteoporosis International

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“…One specimen of human femoral cortical bone from a 79-year old patient was collected during standard hemiarthroplasty from the inferior femoral neck, which was chosen because this site is the region where the cortex is the thickest (Werner et al, 1988). Moreover, the femoral neck exhibits a continuum between cortical and trabecular bone.…”

Section: Sample Preparationmentioning

confidence: 99%

Determination of the heterogeneous anisotropic elastic properties of human femoral bone: From nanoscopic to organ scale

Sansalone

Naı̈li

Bousson

et al. 2010

Journal of Biomechanics

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“…Histologic studies indicate that in the midfemoral neck the amount of cancellous bone exceeds that of cortical bone [11]. Furthermore, there is good evidence that cancellous bone contributes significantly to femoral neck strength [12][13][14]. The concept of preferential loss of horizontal trabeculae with aging in the vertebra is well recognized [15].…”

Section: Antiresorptive Agents Improve Bone Strength By Maintaining Tmentioning

confidence: 99%

The Impact of Bone Turnover and Bone-Active Agents on Bone Quality: Focus on the Hip

Dempster

2002

Osteoporosis International

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Contribution of the trabecular component to mechanical strength and bone mineral content of the femoral neck. An experimental study on cadaver bones

Cited by 31 publications

References 0 publications

Age-Related Cancellous Bone Loss in the Proximal Femur of Caucasian Females

Age-Related Cancellous Bone Loss in the Proximal Femur of Caucasian Females

Determination of the heterogeneous anisotropic elastic properties of human femoral bone: From nanoscopic to organ scale

The Impact of Bone Turnover and Bone-Active Agents on Bone Quality: Focus on the Hip

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