Contribution to<i>in vitro</i>screening of Egyptian plants for schistosomicidal activity

Yousif, Fouad; Wassel, G. M.; Boulos, Loutfy; Labib, Therese; Mahmoud, Khaled F.; El‐Hallouty, Salwa M.; Bardicy, Samia El; Mahmoud, Soheir; Ramzy, Fatem; Gohar, Lamiaa; El-Manawaty, May A.; Gendy, Mohamed A.M. El; Fayad, Walid; El-Menshawi, Bassem S.

doi:10.3109/13880209.2011.625952

Cited by 29 publications

(19 citation statements)

References 17 publications

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“…Saponins also possess hemolytic action by forming complexes with cholesterol in red blood cell membranes causing their collapse and release of hemoglobin [6] . Formerly, the methanol plant extract of C. viminalis was tested to evaluate the anti-schistosomal activity and the results revealed high effect since the LC 50 (≤ 15 µg/ ml) was very low [32] which agrees with our results regarding C. citrinus.…”

Section: Discussionsupporting

confidence: 87%

In vitro assessment of Schistosoma mansoni cercaricidal activities of Solanum nigrum and Callistemon citrinius leaves extracts and cercarial genetic changes by RAPD-PCR

Sadek

Harba

Faheem

2019

Parasitologists United Journal

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Section: Discussionsupporting

confidence: 87%

In vitro assessment of Schistosoma mansoni cercaricidal activities of Solanum nigrum and Callistemon citrinius leaves extracts and cercarial genetic changes by RAPD-PCR

Sadek

Harba

Faheem

2019

Parasitologists United Journal

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“…The discovery of pure compounds as active principles in plants was first described at the beginning of the 19th century [9]. As a result, several extracts or natural compounds from plants with promising antischistosomal properties have been identified [9–15]. In this context, natural products and natural product-derived compounds are gaining prominence as possible sources of new drugs in the control and treatment of schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Assessment of Anthelmintic Activities ofRauwolfia vomitoria(Apocynaceae) Stem Bark and Roots against Parasitic Stages ofSchistosoma mansoniand Cytotoxic Study

Tekwu

Bosompem

Anyan

et al. 2017

Journal of Parasitology Research

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Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni. Both plant parts were found to be active against cercariae and adult worms. Within 2 h of exposure all cercariae were killed at a concentration range of 62.5–1000 µg/mL and 250–1000 µg/mL of R. vomitoria stem bark and roots, respectively. The LC50 values determined for the stem bark after 1 and 2 h of exposure were 207.4 and 61.18 µg/mL, respectively. All adult worms exposed to the concentrations range of 250–1000 µg/mL for both plant parts died within 120 h of incubation. The cytotoxic effects against HepG2 and Chang liver cell assessed using MTT assay method indicated that both plant extracts which were inhibitory to the proliferation of cell lines with IC50 > 20 μg/mL appear to be safe. This report provides the first evidence of in vitro schistosomicidal potency of R. vomitoria with the stem bark being moderately, but relatively, more active and selective against schistosome parasites. This suggests the presence of promising medicinal constituent(s).

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“…Studies of African plant species and their molluscicidal activity are summarized in Table 4. [98]. Moreover, in Egypt, another study on asparagaline A, a triterpenoid isolated from roots of an African plant Asparagus stipularis Forss., demonstrated its activity against S. mansoni [99].…”

Section: Recent Scientific Studies On Molluscicide Activitymentioning

confidence: 99%

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

Albuquerque

Mahomoodally

Lobine

et al. 2020

Biology

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Schistosomiasis, a parasitic disease caused by trematodes of the genus Schistosoma, is the second most prevalent parasitic disease in the world. It affects around 200 million people. Clinical treatment, prophylaxis, and prevention are performed in countries susceptible to schistosomiasis. In the pharmacological treatment for an acute form of schistosomiasis, the use of antiparasitics, mainly praziquantel, is more common. As an alternative way, prevention methods such as reducing the population of intermediate hosts (mollusks) with molluscicides are important in the control of this disease by interrupting the biological cycle of this etiological parasite. Despite the importance of pharmacological agents and molluscicides, they have side effects and environmental toxicity. In addition, they can lead to the development of resistance enhancing of parasites, and lead to the search for new and effective drugs, including resources of vegetal origin, which in turn, are abundant in the affected countries. Thus, the purpose of this review is to summarize recent studies on botanical products with potential for the control of schistosomiasis, including anti-Schistosoma and molluscicide activities. In addition, species and plant derivatives according to their origin or geographical importance indicating a possible utility of local resources for countries most affected by the disease are presented.

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Contribution toin vitroscreening of Egyptian plants for schistosomicidal activity

Abstract: These species may represent additional natural sources of bioactive material that deserve further investigation for drug discovery against schistosomiasis.

Cited by 29 publications

References 17 publications

In vitro assessment of Schistosoma mansoni cercaricidal activities of Solanum nigrum and Callistemon citrinius leaves extracts and cercarial genetic changes by RAPD-PCR

In vitro assessment of Schistosoma mansoni cercaricidal activities of Solanum nigrum and Callistemon citrinius leaves extracts and cercarial genetic changes by RAPD-PCR

In Vitro Assessment of Anthelmintic Activities ofRauwolfia vomitoria(Apocynaceae) Stem Bark and Roots against Parasitic Stages ofSchistosoma mansoniand Cytotoxic Study

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions

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