Synthetic esters have become more and more popular in last few decades, explaining the increasing number of units filled with this liquid year by year. They have been investigated under different aspects, both from the fundamental point of view and breakdown mechanisms, well as from the application point of view. However, their use in high voltage equipment is always a challenge and deeper knowledge of the various aspects that can be encountered in their exploitation is needed. The intent of this review paper is to present the recent research progress on synthetic ester liquid in relation to the selected issues, most important for ester development in the authors’ opinion. The described issues are the breakdown performance of synthetic esters, lightning impulse strength and pre-breakdown phenomena of synthetic esters, synthetic esters-based nanofluids, combined paper-synthetic ester based insulating systems, application of synthetic ester for retro-filling and drying of mineral oil-immersed transformers, DGA(dissolved gas analysis)-based diagnosis of synthetic esters filled transformers as well as static electrification of synthetic esters. The different sections are based both on the data available in the literature, but above all on the authors’ own experience from their research work on synthetic ester liquids for electrical application purposes.