Novel phenoxy derivative Juvenile Hormone Analogs (JHAs) -pyriproxyfen and diofenolan were used to evaluate their efficacy against last instar larvae of polyphagous pest Spodoptera litura. Sixth instar day 1-3 old larvae were treated with different doses of pyriproxyfen and diofenolan. The JHAs disrupted the growth, development, molting and metamorphosis in S . l it u ra t r e a t e d l a r v a e. B o t h t he J H A spyriproxyfen and diofenolan were found to be equally potent in their effects. The larval duration was prolonged apart from inducing several malformations. They effectively controlled the polyphagous pest S. litura by inducing mortality, ecdysial failure, production of larval -pupal mosaics, reduced pupation, production of abnormal pupae, complete suppression of normal adult emergence and production of deformed non-viable adultoids. Being stable, posing minimal threat to non-target organisms including fish and birds, beneficial insects and safe to environment and humans, both these JHAs can be judicially incorporated into IPM programs along with other bio-rational methods for the successful control of polyphagous pest S. litura.