Contributions of childhood abuse and neglect to reward neural substrates in adolescence

Yang, Ruiyu; Yu, Qiongru; Owen, Cassidy Elizabeth; Aspe, Gabriele Ibarra; Wiggins, Jillian Lee

doi:10.1016/j.nicl.2021.102832

Cited by 14 publications

(6 citation statements)

References 42 publications

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“…50 Sixth, ACEs can affect brain development and function, including brain's reward system, making children more prone to seeking out substances to experience pleasure or relief. 51 Finally, substance use can perpetuate a cycle of adverse experiences, as it can lead to criminal behaviors, legal problems, and further adverse events, creating a negative feedback loop. 52 Early identification of these mechanisms as well as substance use initiation patterns can help develop early interventions, access to mental health services, supportive relationships, and resiliencebuilding strategies for children to cope with their experiences.…”

Section: Discussionmentioning

confidence: 99%

“…Fifth, children who have experienced ACEs may be more vulnerable to peer pressure and external influences, including associations with peers who use substances 50 . Sixth, ACEs can affect brain development and function, including brain's reward system, making children more prone to seeking out substances to experience pleasure or relief 51 . Finally, substance use can perpetuate a cycle of adverse experiences, as it can lead to criminal behaviors, legal problems, and further adverse events, creating a negative feedback loop 52 .…”

Section: Discussionmentioning

confidence: 99%

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Adverse Childhood Experience‐Related Conditions and Substance Use in Adolescents: A Secondary Analysis of Cross‐Sectional Survey Data

Jayawardene,

Lohrmann,

Agley

et al. 2024

Journal of School Health

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BACKGROUNDAdverse childhood experiences (ACEs) cluster within children. In addition to standardized ACE measures, there exist “ACE‐related” measures that are either directly or indirectly related to the standardized ACE constructs. This study aimed to identify ACE‐related latent classes of adolescents and describe past‐month substance use in each class by sex and race/ethnicity.METHODSData from the 2018 Indiana Youth Survey (N = 70,703), which is a repeated self‐administered, cross‐sectional survey, were used. Latent class analysis was conducted using ACE‐related family (parent incarceration, insulting/yelling within family, inability to discuss personal problems) and school (hate being in school, feeling unsafe, inability to talk to teachers one‐on‐one) items. Dependent variable combined past 30‐day use‐frequency of 17 substances. Two‐way analysis of variances examined ACE by sex and race/ethnicity interaction.RESULTSFour ACE‐related classes emerged: “Family‐Only” (11.2%), “School‐Only” (16.5%), “Family‐School” (8.0%), and “No‐ACE” (64.3%). Substance use was highest in “Family‐School” (mean = 0.67); lowest in “No‐ACE” (mean = 0.21). Significant race/ethnicity (F = 27.06; p < .0001), ACE * sex interaction (F = 12.13; p < .0001) and ACE * race/ethnicity interaction (F = 4.57; p < .0001) effects emerged. Within each ACE‐related class, substance use was lowest for Asians and highest for Hispanics.CONCLUSIONSAdverse childhood experience‐related items cluster within children across school and family environments and clustering differs by race/ethnicity, but not by sex. Incorporating ACE‐related items into school surveys enhances the ability to implement interventions that target relationships between ACEs and substance use.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adverse Childhood Experience‐Related Conditions and Substance Use in Adolescents: A Secondary Analysis of Cross‐Sectional Survey Data

Jayawardene,

Lohrmann,

Agley

et al. 2024

Journal of School Health

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“…Furthermore, these deficits may cause more social withdrawal and limited interpersonal relationships, which further decrease interest in caring for others ( Music, 2011 ). Additionally, some studies have found that neglect predicts the hyposensitivity of reward and blunted reward processing ( Bounoua et al, 2021 ; Yang et al, 2021 ). In this case, children who have experienced neglect would be less likely to associate prosocial behavior with positive social consequences (such as obtaining social reward or a good reputation or avoiding social punishment), which would in turn reduce the willingness to engage in prosocial behavior.…”

Section: Discussionmentioning

confidence: 99%

How do childhood abuse and neglect affect prosocial behavior? The mediating roles of different empathic components

Chen

Zhang²,

Sun³

et al. 2023

Front. Psychol.

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BackgroundChildhood abuse and neglect are typically considered as two different forms of maltreatment. Previous international studies have found differential effects of abuse and neglect on prosocial behavior, but this and the mediating pathway underlying these associations have not been examined in a Chinese sample. Our study aims to examine the effects of childhood abuse and neglect on prosocial behavior in Chinese participants and test the unique mediating roles of different empathic components in these associations.MethodsA total of 1,569 young adults (average age = 18.17 years) were recruited from a college that enrolls students from all provinces of China. Participants completed a series of questionnaires, including the Childhood Trauma Questionnaire, Interpersonal Reactivity Index, and Prosocial Tendencies Measure. Path analysis was conducted to determine the mediational relationships.ResultsEmotional neglect had significant direct effect on prosocial behavior (β = −0.108, p < 0.001), and could also impact prosocial behavior through the mediating roles of perspective-taking and empathic concern (effect size = −0.091 and −0.097 respectively, p < 0.001). Emotional abuse affected prosocial behavior only through personal distress (effect size = −0.072, p < 0.001). Physical abuse, sexual abuse and physical neglect have little effect on prosocial behavior and empathy.ConclusionChildhood abuse and neglect have distinct influences on prosocial behavior. Emotional abuse and emotional neglect affect prosocial behavior through distinct pathways. This conclusion could help to establish precise interventions for improving prosocial behavior in maltreated individuals.

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“…Monetary incentive delay task ( Birn et al, 2017 ; Boecker-Schlier et al, 2016 ; DelDonno et al, 2019 ; Dennison et al, 2016 ; Dennison et al, 2019 ; Dillon et al, 2009 ; Hendrikse et al, 2022 ; Mehta et al, 2010 ; Morelli et al, 2021 ; Sheridan et al, 2018 ; Yang et al, 2021 )…”

Section: Methodsmentioning

confidence: 99%

How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

Ruge,

Ehlers,

Kastrinogiannis

et al. 2024

eLife

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Adverse childhood experiences (ACEs) are a major risk factor for the development of multiple psychopathological conditions, but the mechanisms underlying this link are poorly understood. Associative learning encompasses key mechanisms through which individuals learn to link important environmental inputs to emotional and behavioral responses. ACEs may impact the normative maturation of associative learning processes, resulting in their enduring maladaptive expression manifesting in psychopathology. In this review, we lay out a systematic and methodological overview and integration of the available evidence of the proposed association between ACEs and threat and reward learning processes. We summarize results from a systematic literature search (following PRISMA guidelines) which yielded a total of 81 articles (threat: n=38, reward: n=43). Across the threat and reward learning fields, behaviorally, we observed a converging pattern of aberrant learning in individuals with a history of ACEs, independent of other sample characteristics, specific ACE types, and outcome measures. Specifically, blunted threat learning was reflected in reduced discrimination between threat and safety cues, primarily driven by diminished responding to conditioned threat cues. Furthermore, attenuated reward learning manifested in reduced accuracy and learning rate in tasks involving acquisition of reward contingencies. Importantly, this pattern emerged despite substantial heterogeneity in ACE assessment and operationalization across both fields. We conclude that blunted threat and reward learning may represent a mechanistic route by which ACEs may become physiologically and neurobiologically embedded and ultimately confer greater risk for psychopathology. In closing, we discuss potentially fruitful future directions for the research field, including methodological and ACE assessment considerations.

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Contributions of childhood abuse and neglect to reward neural substrates in adolescence

Cited by 14 publications

References 42 publications

Adverse Childhood Experience‐Related Conditions and Substance Use in Adolescents: A Secondary Analysis of Cross‐Sectional Survey Data

Adverse Childhood Experience‐Related Conditions and Substance Use in Adolescents: A Secondary Analysis of Cross‐Sectional Survey Data

How do childhood abuse and neglect affect prosocial behavior? The mediating roles of different empathic components

How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

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