Contributions of <i>PARP‐1</i> rs1136410 C&gt;T polymorphism to the development of cancer

Li, Hunian; Zha, Yong-Jiu; Du, Fang; Liu, Jie; Li, Xiaoquan; Zhao, Xu

doi:10.1111/jcmm.16027

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…PARP1 polymorphism Val762Ala (rs1136410 T>C) may be associated with prostate cancer (106), esophageal squamous cell carcinoma (107), and breast cancer (108). Recent meta-analyses found a borderline significant association between PARP1 Val762Ala polymorphism and overall cancer risk, although after stratification by cancer types, the polymorphism could predispose to gastric cancer, thyroid cancer and cervical cancer, in an Asian population, but not in Caucasian and African populations (109,110). Involuntary smoking was associated with an increased risk of breast cancer among both preand postmenopausal women, depending on the genotype of PARP1 762 (111), while Ala762Ala (rs1136410 C/C) genotype was associated with an elevated risk of esophageal squamous cell carcinoma in smokers compared to T/T or T/C genotype (107,112).…”

Section: Discussionmentioning

confidence: 99%

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Vital

Antunes

Louro

et al. 2021

Front. Public Health

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Environmental tobacco smoke (ETS) has been recognized as a major health hazard by environmental and public health authorities worldwide. In Portugal, smoke-free laws are in force for some years, banning smoking in most indoor public spaces. However, in hospitality venues such as restaurants and bars, owners can still choose between a total smoke-free policy or a partial smoking restriction with designated smoking areas, if adequate reinforced ventilation systems are implemented. Despite that, a previous study showed that workers remained continuously exposed to higher ETS pollution in Lisbon restaurants and bars where smoking was still allowed, comparatively to total smoke-free venues. This was assessed by measurements of indoor PM2.5 and urinary cotinine, a biomarkers of tobacco smoke exposure, demonstrating that partial smoking restrictions do not effectively protect workers from ETS. The aim of the present work was to characterize effect and susceptibility biomarkers in non-smokers from those hospitality venues occupationally exposed to ETS comparatively to non-exposed ones. A group of smokers was also included for comparison. The sister chromatid exchange (SCE), micronucleus (MN) and comet assays in whole peripheral blood lymphocytes (PBLs) and the micronucleus assay in exfoliated buccal cells, were used as biomarkers of genotoxicity. Furthermore, a comet assay after ex vivo challenge of leukocytes with an alkylating agent, ethyl methanesulfonate (EMS), was used to analyze the repair capacity of those cells. Genetic polymorphisms in genes associated with metabolism and DNA repair were also included. The results showed no clear association between occupational exposure to ETS and the induction of genotoxicity. Interestingly, the leukocytes from non-smoking ETS-exposed individuals displayed lower DNA damage levels in response to the ex vivo EMS challenge, in comparison to those from non-exposed workers, suggesting a possible adaptive response. The contribution of individual susceptibility to the effect biomarkers studied was unclear, deserving further investigation.

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Section: Discussionmentioning

confidence: 99%

Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars

Vital

Antunes

Louro

et al. 2021

Front. Public Health

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“…In a meta-analysis, Li et al collected research results on PARP1 polymorphisms [ 88 ]. The authors showed that the rs1136410 polymorphism has a significant association with the overall risk of cancer, and detailed subgroup analyses showed that it may significantly predispose to stomach cancer, thyroid cancer, and cervical cancer while protecting against brain cancer.…”

Section: Polymorphism Of Genes Encoding Dna Repair Proteins In Thyroi...mentioning

confidence: 99%

Polymorphisms of DNA Repair Genes in Thyroid Cancer

Gielecińska,

Kciuk,

Kołat

et al. 2024

IJMS

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The incidence of thyroid cancer, one of the most common forms of endocrine cancer, is increasing rapidly worldwide in developed and developing countries. Various risk factors can increase susceptibility to thyroid cancer, but particular emphasis is put on the role of DNA repair genes, which have a significant impact on genome stability. Polymorphisms of these genes can increase the risk of developing thyroid cancer by affecting their function. In this article, we present a concise review on the most common polymorphisms of selected DNA repair genes that may influence the risk of thyroid cancer. We point out significant differences in the frequency of these polymorphisms between various populations and their potential relationship with susceptibility to the disease. A more complete understanding of these differences may lead to the development of effective prevention strategies and targeted therapies for thyroid cancer. Simultaneously, there is a need for further research on the role of polymorphisms of previously uninvestigated DNA repair genes in the context of thyroid cancer, which may contribute to filling the knowledge gaps on this subject.

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“…This SNP has been linked to both lung cancer and follicular lymphoma through the HyDn-SNP-S method (2,3). The rs1136410 SNP has also been shown to serve as a protective factor against breast cancer and coronary artery disease in the Han Chinese population, but it may lead to an increased overall risk of age-related cataracts and cancers (61)(62)(63)(64)(65).…”

Section: Introductionmentioning

confidence: 99%