Contributions of Larry E. Becker to Neuropathologic Research in the Sudden Infant Death Syndrome: A Tribute

Kinney, Hannah C.

doi:10.1007/s10024-005-3176-8

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…This finding is consistent with the pathological studies showing that catecholamines may be responsible for SIDS [27–29]. Our former data show that retrogradely labeled neurons from the caudal nucleus ambiguous are located in the SolDL and SolIM, and some of the retrogradely labeled neurons in the SolDL also expressed TH-ir at the level of 0.6 mm to 0.2 mm caudal to the obex [57], consistent with our present results, further indicating that SolDL catecholaminergic neurons may send direct projections to the LMN during the LCR.…”

Section: Discussionsupporting

confidence: 93%

“…The nuclei showing overlap of serotoninergic regions with laryngeal pre-motoneurons were the raphe nuclei [15,25,26]. Furthermore, studies of SIDS pathology have emphasized the functions of catecholamines [27–29] and the significance of the medullary serotonin pathway [30]. Therefore, it is assumed that the medullary catecholaminergic and serotoninergic neurons may play important roles in the control of the LCR.…”

Section: Introductionmentioning

confidence: 99%

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Distribution of Fos-Like Immunoreactivity, Catecholaminergic and Serotoninergic Neurons Activated by the Laryngeal Chemoreflex in the Medulla Oblongata of Rats

2015

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The laryngeal chemoreflex (LCR) induces apnea, glottis closure, bradycardia and hypertension in young and maturing mammals. We examined the distribution of medullary nuclei that are activated by the LCR and used immunofluorescent detection of Fos protein as a cellular marker for neuronal activation to establish that the medullary catecholaminergic and serotoninergic neurons participate in the modulation of the LCR. The LCR was elicited by the infusion of KCl-HCl solution into the laryngeal lumen of adult rats in the experimental group, whereas the control group received the same surgery but no infusion. In comparison, the number of regions of Fos-like immunoreactivity (FLI) that were activated by the LCR significantly increased in the nucleus of the solitary tract (NTS), the vestibular nuclear complex (VNC), the loose formation of the nucleus ambiguus (AmbL), the rostral ventral respiratory group (RVRG), the ventrolateral reticular complex (VLR), the pre-Bötzinger complex (PrBöt), the Bötzinger complex (Böt), the spinal trigeminal nucleus (SP5), and the raphe obscurus nucleus (ROb) bilaterally from the medulla oblongata. Furthermore, 12.71% of neurons with FLI in the dorsolateral part of the nucleus of the solitary tract (SolDL) showed tyrosine hydroxylase-immunoreactivity (TH-ir, catecholaminergic), and 70.87% of neurons with FLI in the ROb were serotoninergic. Our data demonstrated the distribution of medullary nuclei that were activated by the LCR, and further demonstrated that catecholaminergic neurons of the SolDL and serotoninergic neurons of the ROb were activated by the LCR, indicating the potential central pathway of the LCR.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Distribution of Fos-Like Immunoreactivity, Catecholaminergic and Serotoninergic Neurons Activated by the Laryngeal Chemoreflex in the Medulla Oblongata of Rats

2015

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“…In many SIDS cases, arcuate nucleus hypoplasia, periventricular leukomalacia and brain nucleus subtle gliosis can be found (Keeling, 2009b). Relatively, gliosis in the brain is a common finding (Kinney, 2005). Also continuing hematopoiesis in the liver is one of the findings of SIDS and found to be significantly higher, compared with the control group (Töro et al, 2007).…”

Section: Fetal and Perinatal Deathsmentioning

confidence: 99%